Human Gene RIMKLA (uc001chi.2)
Description: Homo sapiens ribosomal modification protein rimK-like family member A (RIMKLA), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:42,846,468-42,889,900 Size: 43,433 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr1:42,846,606-42,880,645 Size: 34,040 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RIMKA_HUMAN
DESCRIPTION: RecName: Full=N-acetylaspartyl-glutamate synthetase A; Short=NAAG synthetase A; Short=NAAGS; EC=6.3.2.n6; AltName: Full=Ribosomal protein S6 modification-like protein A;
FUNCTION: Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG).CATALYTIC ACTIVITY: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate.COFACTOR: Binds 2 manganese ions per subunit (By similarity).SUBCELLULAR LOCATION: Cytoplasm (Probable).MISCELLANEOUS: N-acetylaspartyl-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS) (By similarity).SIMILARITY: Belongs to the RimK family.SIMILARITY: Contains 1 ATP-grasp domain.SEQUENCE CAUTION: Sequence=AAH39737.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH70661.1; Type=Erroneous gene model prediction;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011761 - ATP-grasp
IPR013651 - ATP-grasp_RimK-type
IPR013815 - ATP_grasp_subdomain_1
IPR013816 - ATP_grasp_subdomain_2
IPR004666 - RpS6_RimK/Lys_biosynth_LsyX
Pfam Domains: PF02655 - ATP-grasp domain
PF02955 - Prokaryotic glutathione synthetase, ATP-grasp domain
PF08443 - RimK-like ATP-grasp domain
SCOP Domains: 56059 - Glutathione synthetase ATP-binding domain-like
ModBase Predicted Comparative 3D Structure on Q8IXN7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
HQ448023 - Synthetic construct Homo sapiens clone IMAGE:100071397; CCSB010253_02 family with sequence similarity 80, member A (FAM80A) gene, encodes complete protein.KJ904141 - Synthetic construct Homo sapiens clone ccsbBroadEn_13535 RIMKLA gene, encodes complete protein.BC039737 - Homo sapiens ribosomal modification protein rimK-like family member A, mRNA (cDNA clone MGC:47816 IMAGE:6021672), complete cds.JD026838 - Sequence 7862 from Patent EP1572962.JD032144 - Sequence 13168 from Patent EP1572962.JD035142 - Sequence 16166 from Patent EP1572962.JD217822 - Sequence 198846 from Patent EP1572962.JD231983 - Sequence 213007 from Patent EP1572962.JD368554 - Sequence 349578 from Patent EP1572962.JD177521 - Sequence 158545 from Patent EP1572962.JD361146 - Sequence 342170 from Patent EP1572962.JD309209 - Sequence 290233 from Patent EP1572962.JD309210 - Sequence 290234 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q8IXN7 (Reactome details) participates in the following event(s):R-HSA-8942575 N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism
Other Names for This Gene
Alternate Gene Symbols: FAM80A, NM_173642, NP_775913, Q5VUS5, Q8IXN7, RIMKA_HUMANUCSC ID: uc001chi.2RefSeq Accession: NM_173642
Protein: Q8IXN7
(aka RIMKA_HUMAN)
CCDS: CCDS466.2
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_173642.3
exon count:
5 CDS single in 3' UTR:
no
RNA size:
10583
ORF size:
1176 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2552.00 frame shift in genome:
no
% Coverage:
99.87
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.