Description: Homo sapiens ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (ATP6V0B), transcript variant 2, mRNA. RefSeq Summary (NM_001039457): This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. Transcript (Including UTRs) Position: hg19 chr1:44,440,602-44,443,972 Size: 3,371 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr1:44,441,787-44,443,679 Size: 1,893 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99437
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0007035 vacuolar acidification GO:0008286 insulin receptor signaling pathway GO:0015991 ATP hydrolysis coupled proton transport GO:0016241 regulation of macroautophagy GO:0033572 transferrin transport GO:0034220 ion transmembrane transport GO:1902600 hydrogen ion transmembrane transport