ID:NDC1_HUMAN DESCRIPTION: RecName: Full=Nucleoporin NDC1; Short=hNDC1; AltName: Full=Transmembrane protein 48; FUNCTION: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. SUBUNIT: Interacts with the NUP35/NUP53 (By similarity). SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex. SIMILARITY: Belongs to the NDC1 family. SEQUENCE CAUTION: Sequence=BAB14135.1; Type=Erroneous initiation; Sequence=BAC03665.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09531 - Nucleoporin protein Ndc1-Nup
ModBase Predicted Comparative 3D Structure on Q9BTX1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
