Description: Homo sapiens cytochrome P450, family 2, subfamily J, polypeptide 2 (CYP2J2), mRNA. RefSeq Summary (NM_000775): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr1:60,358,980-60,392,423 Size: 33,444 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr1:60,359,323-60,392,418 Size: 33,096 Coding Exon Count: 9
asthma Polonikov, A. V. et al. 2007, PROMOTER POLYMORPHISM G-50T OF A HUMAN CYP2J2 EPOXYGENASE GENE IS ASSOCIATED WITH COMMON SUSCEPTIBILITY TO ASTHMA, Chest 2007.
[PubMed 17475630]
Our data demonstrate for the first time that the CYP2J2 gene might be considered as a novel candidate gene for common susceptibility to asthma and highlight the importance of the P-450 epoxygenase pathway of metabolism of arachidonic acid in the pathogenesis of the disease.
atherosclerosis, coronary Spiecker, M. et al. 2004, Risk of Coronary Artery Disease Associated With Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2, Circulation. 2004 Oct;110(15):2132-6.
[PubMed 15466638]
A functionally relevant polymorphism of the CYP2J2 gene is independently associated with an increased risk of coronary artery disease.
Factor VII Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903294]
Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51589
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0008392 arachidonic acid epoxygenase activity GO:0008404 arachidonic acid 14,15-epoxygenase activity GO:0008405 arachidonic acid 11,12-epoxygenase activity GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0020037 heme binding GO:0046872 metal ion binding GO:0070330 aromatase activity GO:0071614 linoleic acid epoxygenase activity
Biological Process: GO:0006690 icosanoid metabolic process GO:0006805 xenobiotic metabolic process GO:0008016 regulation of heart contraction GO:0019373 epoxygenase P450 pathway GO:0043651 linoleic acid metabolic process GO:0055114 oxidation-reduction process
US Server
