Description: Homo sapiens TM2 domain containing 1 (TM2D1), mRNA. RefSeq Summary (NM_032027): The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr1:62,146,719-62,191,095 Size: 44,377 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr1:62,149,108-62,190,792 Size: 41,685 Coding Exon Count: 6
ID:TM2D1_HUMAN DESCRIPTION: RecName: Full=TM2 domain-containing protein 1; AltName: Full=Beta-amyloid-binding protein; Short=hBBP; Flags: Precursor; FUNCTION: May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42. SUBUNIT: Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed. PTM: N-glycosylated. SIMILARITY: Belongs to the TM2 family. CAUTION: Was originally (PubMed:11278849) thought to modulate beta-amyloid toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BX74
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
