Description: Homo sapiens serine/arginine-rich splicing factor 11 (SRSF11), transcript variant 1, mRNA. RefSeq Summary (NM_004768): This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr1:70,695,961-70,717,701 Size: 21,741 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr1:70,701,214-70,716,488 Size: 15,275 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q05519
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC022815 - Homo sapiens, clone IMAGE:4639478, mRNA. BC032727 - Homo sapiens splicing factor, arginine/serine-rich 11, mRNA (cDNA clone IMAGE:5532638), partial cds. AK310447 - Homo sapiens cDNA, FLJ17489. BC040436 - Homo sapiens splicing factor, arginine/serine-rich 11, mRNA (cDNA clone MGC:48837 IMAGE:5518580), complete cds. M74002 - Human arginine-rich nuclear protein mRNA, complete cds. AK300147 - Homo sapiens cDNA FLJ58939 complete cds, highly similar to Splicing factor arginine/serine-rich 11. BC017359 - Homo sapiens splicing factor, arginine/serine-rich 11, mRNA (cDNA clone IMAGE:5092873), partial cds. AK301670 - Homo sapiens cDNA FLJ52287 complete cds, highly similar to Splicing factor arginine/serine-rich 11. BC002784 - Homo sapiens splicing factor, arginine/serine-rich 11, mRNA (cDNA clone IMAGE:3615263), partial cds. BC009840 - Homo sapiens splicing factor, arginine/serine-rich 11, mRNA (cDNA clone IMAGE:3845506), partial cds. CU691872 - Synthetic construct Homo sapiens gateway clone IMAGE:100021205 5' read SFRS11 mRNA. KJ892736 - Synthetic construct Homo sapiens clone ccsbBroadEn_02130 SRSF11 gene, encodes complete protein. BX640645 - Homo sapiens mRNA; cDNA DKFZp686P22142 (from clone DKFZp686P22142). AL832279 - Homo sapiens mRNA; cDNA DKFZp667E0418 (from clone DKFZp667E0418). BX641004 - Homo sapiens mRNA; cDNA DKFZp686D02116 (from clone DKFZp686D02116). BX537679 - Homo sapiens mRNA; cDNA DKFZp686M13204 (from clone DKFZp686M13204). JD250991 - Sequence 232015 from Patent EP1572962. JD291376 - Sequence 272400 from Patent EP1572962. JD273157 - Sequence 254181 from Patent EP1572962. AB062486 - Homo sapiens OK/SW-cl.33 mRNA, partial cds. JD048412 - Sequence 29436 from Patent EP1572962. JD244516 - Sequence 225540 from Patent EP1572962. JD115249 - Sequence 96273 from Patent EP1572962. JD403693 - Sequence 384717 from Patent EP1572962. JD156437 - Sequence 137461 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q05519 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)