Human Gene GPR61 (uc001dxy.2)
  Description: Homo sapiens G protein-coupled receptor 61 (GPR61), mRNA.
RefSeq Summary (NM_031936): This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:110,082,494-110,088,455 Size: 5,962 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:110,085,645-110,087,000 Size: 1,356 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:110,082,494-110,088,455)mRNA (may differ from genome)Protein (451 aa)
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR61_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 61; AltName: Full=Biogenic amine receptor-like G-protein coupled receptor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAK12637.1; Type=Frameshift; Positions=415;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GPR61
CDC HuGE Published Literature: GPR61

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.19 RPKM in Pituitary
Total median expression: 27.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -255.50683-0.374 Picture PostScript Text
3' UTR -290.84784-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9BZJ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:1990763 arrestin family protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK290027 - Homo sapiens cDNA FLJ77028 complete cds, highly similar to Homo sapiens G protein-coupled receptor 61 (GPR61), mRNA.
AF258342 - Homo sapiens biogenic amine receptor-like protein mRNA, complete cds.
AB209096 - Homo sapiens premature mRNA for G protein-coupled receptor 61 variant.
JD126286 - Sequence 107310 from Patent EP1572962.
JD037426 - Sequence 18450 from Patent EP1572962.
BC067464 - Homo sapiens G protein-coupled receptor 61, mRNA (cDNA clone MGC:79297 IMAGE:6971762), complete cds.
JD523676 - Sequence 504700 from Patent EP1572962.
AB384849 - Synthetic construct DNA, clone: pF1KB3736, Homo sapiens GPR61 gene for G-protein coupled receptor 61, complete cds, without stop codon, in Flexi system.
KJ905566 - Synthetic construct Homo sapiens clone ccsbBroadEn_15182 GPR61 gene, encodes complete protein.
AF317652 - Homo sapiens G protein-coupled receptor (GPR61) mRNA, complete cds.
JF810889 - Homo sapiens G protein-coupled receptor 61 (GPR61) mRNA, complete cds.
BC095507 - Homo sapiens G protein-coupled receptor 61, mRNA (cDNA clone IMAGE:6912804), containing frame-shift errors.
JD129221 - Sequence 110245 from Patent EP1572962.
JD459827 - Sequence 440851 from Patent EP1572962.
JD323638 - Sequence 304662 from Patent EP1572962.
JD235621 - Sequence 216645 from Patent EP1572962.
JD281757 - Sequence 262781 from Patent EP1572962.
JD418538 - Sequence 399562 from Patent EP1572962.
JD402413 - Sequence 383437 from Patent EP1572962.
JD260697 - Sequence 241721 from Patent EP1572962.
JD186763 - Sequence 167787 from Patent EP1572962.
JD206739 - Sequence 187763 from Patent EP1572962.
JD358738 - Sequence 339762 from Patent EP1572962.
JD094495 - Sequence 75519 from Patent EP1572962.
JD206342 - Sequence 187366 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1W2, BALGR, GPR61_HUMAN, NM_031936, NP_114142, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
UCSC ID: uc001dxy.2
RefSeq Accession: NM_031936
Protein: Q9BZJ8 (aka GPR61_HUMAN or GP61_HUMAN)
CCDS: CCDS801.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: yes RNA accession: NM_031936.4
exon count: 3CDS single in 3' UTR: no RNA size: 2823
ORF size: 1356CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2276.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.