Description: Homo sapiens glutathione S-transferase mu 3 (brain) (GSTM3), transcript variant 1, mRNA. RefSeq Summary (NM_000849): Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]. Transcript (Including UTRs) Position: hg19 chr1:110,276,554-110,283,660 Size: 7,107 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr1:110,279,693-110,282,909 Size: 3,217 Coding Exon Count: 8
ID:GSTM3_HUMAN DESCRIPTION: RecName: Full=Glutathione S-transferase Mu 3; EC=2.5.1.18; AltName: Full=GST class-mu 3; AltName: Full=GSTM3-3; Short=hGSTM3-3; FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene; KM=0.084 mM for glutathione; SUBUNIT: Homodimer. INTERACTION: Self; NbExp=3; IntAct=EBI-350350, EBI-350350; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Testis and brain. PTM: The N-terminus is blocked. SIMILARITY: Belongs to the GST superfamily. Mu family. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain.
asthma Wikman, H. et al. 2002, N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk., Pharmacogenetics. 2002 Apr;12(3):227-33.
[PubMed 11927838]
The results suggest for the first time that in addition to GSTs, the NATs play an important role in inception of asthmatic reactions related to occupational exposure to diisocyanates.
breast cancer Mitrunen, K. et al. 2001, Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer., Cancer epidemiology, biomarkers & prevention. 2001 Mar;10(3):229-36.
[PubMed 11303592]
Our findings support the view that GST genotypes contribute to the individual breast cancer risk, especially in certain combinations.
colorectal cancer Loktionov, A. et al. 2001, Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction betweenGSTM1 and GSTM3 allele variants as a risk-modulating factor., Carcinogenesis. 2001 Jul;22(7):1053-60.
[PubMed 11408349]
Our findings suggest that interactions of polymorphic genotypes within the GSTM gene cluster affect individual susceptibility to colorectal carcinogenesis, the GSTM3*B variant presence being a risk factor especially in combination with the GSTM1-null genotype.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P21266
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006749 glutathione metabolic process GO:0008065 establishment of blood-nerve barrier GO:0008152 metabolic process GO:0018916 nitrobenzene metabolic process GO:0042178 xenobiotic catabolic process GO:0043627 response to estrogen GO:0070458 cellular detoxification of nitrogen compound GO:1901687 glutathione derivative biosynthetic process
US Server
