Human Gene MAGI3 (uc001edh.3)
  Description: Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:113,933,475-114,224,924 Size: 291,450 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg19 chr1:113,933,656-114,224,883 Size: 291,228 Coding Exon Count: 22 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:113,933,475-114,224,924)mRNA (may differ from genome)Protein (1150 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MAGI3
CDC HuGE Published Literature: MAGI3
Positive Disease Associations: Glucose
Related Studies:
  1. Glucose
    , , . [PubMed 0]
  2. Glucose
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.23 RPKM in Thyroid
Total median expression: 121.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.80181-0.579 Picture PostScript Text
3' UTR -7.4041-0.180 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00397 - WW domain
PF00595 - PDZ domain (Also known as DHR or GLGF)
PF00625 - Guanylate kinase

SCOP Domains:
50156 - PDZ domain-like
51045 - WW domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q5TCQ9-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AF257238 - Homo sapiens membrane-associated guanylate kinase MAGI3 mRNA, complete cds.
BC144144 - Homo sapiens cDNA clone IMAGE:9052664, containing frame-shift errors.
BC130409 - Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3, mRNA (cDNA clone MGC:163281 IMAGE:40146440), complete cds.
AF213259 - Homo sapiens membrane-associated guanylate kinase-related MAGI-3 (MAGI-3) mRNA, complete cds.
AB046854 - Homo sapiens mRNA for KIAA1634 protein, partial cds.
JD526163 - Sequence 507187 from Patent EP1572962.
JD218285 - Sequence 199309 from Patent EP1572962.
JD125360 - Sequence 106384 from Patent EP1572962.
AK026417 - Homo sapiens cDNA: FLJ22764 fis, clone KAIA1006.
AK311589 - Homo sapiens cDNA, FLJ18631.
JD262284 - Sequence 243308 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04530 - Tight junction

-  Other Names for This Gene
  Alternate Gene Symbols: BC144144, KIAA1634, NM_152900, NP_690864, Q5TCQ9-2
UCSC ID: uc001edh.3
RefSeq Accession: NM_152900
Protein: Q5TCQ9-2, splice isoform of Q5TCQ9 CCDS: CCDS860.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC144144.1
exon count: 22CDS single in 3' UTR: no RNA size: 3653
ORF size: 3453CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 5838.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.