To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TDRKH CDC HuGE Published Literature: TDRKH Positive Disease Associations: Hemoglobins
, Lipids
, Triglycerides Related Studies:
Hemoglobins Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903294]
Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
Lipids Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
Triglycerides Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2W6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC156177 - Synthetic construct Homo sapiens clone IMAGE:100062408, MGC:190507 tudor and KH domain containing (TDRKH) mRNA, encodes complete protein. BC172470 - Synthetic construct Homo sapiens clone IMAGE:100069164, MGC:199175 tudor and KH domain containing (TDRKH) mRNA, encodes complete protein. AK225160 - Homo sapiens mRNA for Splice isoform 2 of Q9Y2W6 variant, clone: CBR04030. AF119121 - Homo sapiens putative RNA binding protein mRNA, alternatively spliced, complete cds. BC032690 - Homo sapiens tudor and KH domain containing, mRNA (cDNA clone IMAGE:5241008). BC022467 - Homo sapiens tudor and KH domain containing, mRNA (cDNA clone IMAGE:4796384), with apparent retained intron. AF227192 - Homo sapiens tudor and KH domain-containing protein (TDRKH) (TDRKH) mRNA, complete cds. AK056402 - Homo sapiens cDNA FLJ31840 fis, clone NT2RP7000109, highly similar to Tudor and KH domain-containing protein. AK226092 - Homo sapiens mRNA for tudor and KH domain containing variant, clone: ef03729. AK303063 - Homo sapiens cDNA FLJ61003 complete cds, highly similar to Tudor and KH domain-containing protein. AK295948 - Homo sapiens cDNA FLJ54003 complete cds, highly similar to Tudor and KH domain-containing protein. KJ898334 - Synthetic construct Homo sapiens clone ccsbBroadEn_07728 TDRKH gene, encodes complete protein. DQ890822 - Synthetic construct clone IMAGE:100003452; FLH166228.01X; RZPDo839E0386D tudor and KH domain containing (TDRKH) gene, encodes complete protein. DQ896752 - Synthetic construct Homo sapiens clone IMAGE:100011212; FLH166224.01L; RZPDo839E0385D tudor and KH domain containing (TDRKH) gene, encodes complete protein. AB527643 - Synthetic construct DNA, clone: pF1KB5539, Homo sapiens TDRKH gene for tudor and KH domain containing, without stop codon, in Flexi system. AK316279 - Homo sapiens cDNA, FLJ79178 complete cds, highly similar to Tudor and KH domain-containing protein. DQ597075 - Homo sapiens piRNA piR-35141, complete sequence. JD043947 - Sequence 24971 from Patent EP1572962. JD151620 - Sequence 132644 from Patent EP1572962. JD466834 - Sequence 447858 from Patent EP1572962. JD462117 - Sequence 443141 from Patent EP1572962. JD496213 - Sequence 477237 from Patent EP1572962. JD281563 - Sequence 262587 from Patent EP1572962. JD279239 - Sequence 260263 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y2W6 (Reactome details) participates in the following event(s):
R-HSA-5615682 Complexed PIWIL1 binds pre-piRNA R-HSA-5629203 HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH R-HSA-5629237 HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis R-HSA-211000 Gene Silencing by RNA R-HSA-74160 Gene expression (Transcription)
US Server
