Description: Homo sapiens Fc receptor-like 1 (FCRL1), transcript variant 1, mRNA. RefSeq Summary (NM_052938): This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]. Transcript (Including UTRs) Position: hg19 chr1:157,764,194-157,789,940 Size: 25,747 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr1:157,765,889-157,789,827 Size: 23,939 Coding Exon Count: 11
ID:FCRL1_HUMAN DESCRIPTION: RecName: Full=Fc receptor-like protein 1; Short=FcR-like protein 1; Short=FcRL1; AltName: Full=Fc receptor homolog 1; Short=FcRH1; AltName: Full=IFGP family protein 1; Short=hIFGP1; AltName: Full=Immune receptor translocation-associated protein 5; AltName: CD_antigen=CD307a; Flags: Precursor; FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level). INDUCTION: Down-regulated in activated B-cells. PTM: Phosphorylated on tyrosines upon activation. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96LA6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
