Description: Homo sapiens hydroxysteroid (17-beta) dehydrogenase 7 (HSD17B7), mRNA. RefSeq Summary (NM_016371): HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]. Transcript (Including UTRs) Position: hg19 chr1:162,760,496-162,782,608 Size: 22,113 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr1:162,760,591-162,782,210 Size: 21,620 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56937
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0006703 estrogen biosynthetic process GO:0055114 oxidation-reduction process
BioCyc Knowledge Library PWY3DJ-2 - biosynthesis of estrogens PWY3DJ-8 - biosynthesis of androgens PWY66-3 - cholesterol biosynthesis II (via 24,25-dihydrolanosterol) PWY66-341 - cholesterol biosynthesis I PWY66-4 - cholesterol biosynthesis III (via desmosterol)
Reactome (by CSHL, EBI, and GO)
Protein P56937 (Reactome details) participates in the following event(s):
R-HSA-194632 Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) R-HSA-194689 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol R-HSA-191273 Cholesterol biosynthesis R-HSA-8957322 Metabolism of steroids R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism