Description: Homo sapiens transmembrane and coiled-coil domains 1 (TMCO1), transcript variant 1, mRNA. RefSeq Summary (NM_019026): This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and cognitive disability. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. Transcript (Including UTRs) Position: hg19 chr1:165,693,528-165,738,159 Size: 44,632 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr1:165,697,260-165,738,141 Size: 40,882 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01956 - Integral membrane protein DUF106
ModBase Predicted Comparative 3D Structure on J9JIE6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0032469 endoplasmic reticulum calcium ion homeostasis GO:0070588 calcium ion transmembrane transport
Cellular Component: GO:0005783 endoplasmic reticulum GO:0016020 membrane GO:0016021 integral component of membrane GO:0030176 integral component of endoplasmic reticulum membrane
Descriptions from all associated GenBank mRNAs
LF383658 - JP 2014500723-A/191161: Polycomb-Associated Non-Coding RNAs. JD121083 - Sequence 102107 from Patent EP1572962. AY763589 - Homo sapiens xenogeneic cross-immune protein (PCIA3) mRNA, complete cds. AK093302 - Homo sapiens cDNA FLJ35983 fis, clone TESTI2014007, highly similar to Homo sapiens mRNA for putative membrane protein. AY359027 - Homo sapiens clone DNA16438 STMF151 (UNQ151) mRNA, complete cds. AF274935 - Homo sapiens PNAS-10 mRNA, complete cds. BC000104 - Homo sapiens transmembrane and coiled-coil domains 1, mRNA (cDNA clone MGC:1176 IMAGE:3504808), complete cds. AF070626 - Homo sapiens clone 24483 unknown mRNA, parital cds. AB020980 - Homo sapiens mRNA for putative membrane protein, complete cds. AK316080 - Homo sapiens cDNA, FLJ78979 complete cds, highly similar to Transmembrane and coiled-coil domains protein 1. LF320569 - JP 2014500723-A/128072: Polycomb-Associated Non-Coding RNAs. AK298614 - Homo sapiens cDNA FLJ50833 complete cds, highly similar to Transmembrane and coiled-coil domains protein 1. JD192612 - Sequence 173636 from Patent EP1572962. LF320568 - JP 2014500723-A/128071: Polycomb-Associated Non-Coding RNAs. AF277194 - Homo sapiens PNAS-136 mRNA, complete cds. AK316610 - Homo sapiens cDNA, FLJ96894, Homo sapiens putative membrane protein (LOC54499), mRNA. CU674038 - Synthetic construct Homo sapiens gateway clone IMAGE:100018000 5' read TMCO1 mRNA. LF320566 - JP 2014500723-A/128069: Polycomb-Associated Non-Coding RNAs. LF320565 - JP 2014500723-A/128068: Polycomb-Associated Non-Coding RNAs. JD066560 - Sequence 47584 from Patent EP1572962. JD401235 - Sequence 382259 from Patent EP1572962. JD289225 - Sequence 270249 from Patent EP1572962. MA619235 - JP 2018138019-A/191161: Polycomb-Associated Non-Coding RNAs. MA556146 - JP 2018138019-A/128072: Polycomb-Associated Non-Coding RNAs. MA556145 - JP 2018138019-A/128071: Polycomb-Associated Non-Coding RNAs. MA556143 - JP 2018138019-A/128069: Polycomb-Associated Non-Coding RNAs. MA556142 - JP 2018138019-A/128068: Polycomb-Associated Non-Coding RNAs.