Human Gene SHCBP1L (uc001gpv.3)
  Description: Homo sapiens SHC SH2-domain binding protein 1-like (SHCBP1L), mRNA.
RefSeq Summary (NM_030933): This gene encodes a Src homology 2 domain-binding protein 1-like protein. The encoded protein interacts with heat shock 70 kDa protein 2 and may be involved in maintaining spindle integrity during meiosis. This gene is located in region of chromoso0me 1 encompassing a prostate cancer susceptibility locus. [provided by RefSeq, Sep 2016].
Transcript (Including UTRs)
   Position: hg19 chr1:182,869,000-182,922,553 Size: 53,554 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:182,869,118-182,921,119 Size: 52,002 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:182,869,000-182,922,553)mRNA (may differ from genome)Protein (534 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkHGNCLynx
MalacardsMGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SHCBP1L
Diseases sorted by gene-association score: prostate cancer susceptibility (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 93.58 RPKM in Testis
Total median expression: 93.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -353.91695-0.509 Picture PostScript Text
3' UTR -16.20118-0.137 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF05048 - Periplasmic copper-binding protein (NosD)
PF13229 - Right handed beta helix region

SCOP Domains:
51126 - Pectin lyase-like

ModBase Predicted Comparative 3D Structure on Q9BZQ2-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC026086 - Homo sapiens chromosome 1 open reading frame 14, mRNA (cDNA clone IMAGE:4838435), containing frame-shift errors.
LF383645 - JP 2014500723-A/191148: Polycomb-Associated Non-Coding RNAs.
BC026084 - Homo sapiens chromosome 1 open reading frame 14, mRNA (cDNA clone IMAGE:4831282), complete cds.
AF288397 - Homo sapiens C1orf14 mRNA, complete cds.
AF288398 - Homo sapiens C1orf14 mRNA, complete cds.
BC050305 - Homo sapiens chromosome 1 open reading frame 14, mRNA (cDNA clone MGC:48296 IMAGE:4837018), complete cds.
BC144326 - Homo sapiens cDNA clone IMAGE:9052846.
BC132764 - Homo sapiens chromosome 1 open reading frame 14, mRNA (cDNA clone MGC:164395 IMAGE:40146786), complete cds.
HQ258630 - Synthetic construct Homo sapiens clone IMAGE:100073185 chromosome 1 open reading frame 14 (C1orf14) (C1orf14) gene, encodes complete protein.
JC506671 - Sequence 39 from Patent EP2733220.
JC737783 - Sequence 39 from Patent WO2014075939.
MA619222 - JP 2018138019-A/191148: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AF288397, C1orf14, Q9BZQ2-2
UCSC ID: uc001gpv.3
RefSeq Accession: NM_030933
Protein: Q9BZQ2-2, splice isoform of Q9BZQ2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AF288397.1
exon count: 11CDS single in 3' UTR: no RNA size: 2022
ORF size: 1605CDS single in intron: no Alignment % ID: 99.85
txCdsPredict score: 2757.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.