Human Gene TRIM58 (uc001idp.1)
  Description: Homo sapiens tripartite motif containing 58 (TRIM58), mRNA.
RefSeq Summary (NM_001001957): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:248,031,265-248,060,142 Size: 28,878 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:248,058,889-248,059,833 Size: 945 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:248,031,265-248,060,142)mRNA (may differ from genome)Protein (314 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OR2W3_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 2W3; AltName: Full=Olfactory receptor 2W8; AltName: Full=Olfactory receptor OR1-49;
FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2W3";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM58
CDC HuGE Published Literature: TRIM58
Positive Disease Associations: Erythrocyte Indices , Hypertension
Related Studies:
  1. Erythrocyte Indices
    Yoichiro Kamatani et al. Nature genetics 2010, Genome-wide association study of hematological and biochemical traits in a Japanese population., Nature genetics. [PubMed 20139978]
  2. Hypertension
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.42 RPKM in Whole Blood
Total median expression: 28.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.60269-0.355 Picture PostScript Text
3' UTR -95.22309-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q7Z3T1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF327057 - Homo sapiens BIA2 protein mRNA, complete cds.
AK096188 - Homo sapiens cDNA FLJ38869 fis, clone MESAN2013283, weakly similar to 52 KDA RO PROTEIN.
AL080170 - Homo sapiens mRNA; cDNA DKFZp434C091 (from clone DKFZp434C091).
BC074748 - Homo sapiens tripartite motif-containing 58, mRNA (cDNA clone IMAGE:30915208), partial cds.
BX537432 - Homo sapiens mRNA; cDNA DKFZp686N09198 (from clone DKFZp686N09198); complete cds.
BC146848 - Homo sapiens olfactory receptor, family 2, subfamily W, member 3, mRNA (cDNA clone MGC:181951 IMAGE:9056776), complete cds.
EU831764 - Synthetic construct Homo sapiens clone HAIB:100066793; DKFZo008B0821 olfactory receptor, family 2, subfamily W, member 3 protein (OR2W3) gene, encodes complete protein.
EU831842 - Synthetic construct Homo sapiens clone HAIB:100066871; DKFZo004B0822 olfactory receptor, family 2, subfamily W, member 3 protein (OR2W3) gene, encodes complete protein.
DQ588199 - Homo sapiens piRNA piR-55311, complete sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z3T1 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BX537432, NM_001001957, NP_001001957, OR2W3, OR2W3P, OR2W3_HUMAN, OR2W8P, Q6IF06, Q7Z3T1, Q8NG86
UCSC ID: uc001idp.1
RefSeq Accession: NM_001001957
Protein: Q7Z3T1 (aka OR2W3_HUMAN)
CCDS: CCDS31099.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BX537432.1
exon count: 3CDS single in 3' UTR: no RNA size: 1886
ORF size: 945CDS single in intron: no Alignment % ID: 99.39
txCdsPredict score: 1861.00frame shift in genome: no % Coverage: 80.12
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.