Description: Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10), transcript variant 1, mRNA. RefSeq Summary (NM_004641): This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr10:21,823,101-22,032,559 Size: 209,459 Total Exon Count: 24 Strand: + Coding Region Position: hg19 chr10:21,823,574-22,029,163 Size: 205,590 Coding Exon Count: 22
ID:AF10_HUMAN DESCRIPTION: RecName: Full=Protein AF-10; AltName: Full=ALL1-fused gene from chromosome 10 protein; FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. SUBUNIT: Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed abundantly in testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. SIMILARITY: Contains 2 PHD-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AF10.html";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MLLT10 CDC HuGE Published Literature: MLLT10 Positive Disease Associations: Meningioma Related Studies:
Meningioma Sara E Dobbins et al. Nature genetics 2011, Common variation at 10p12.31 near MLLT10 influences meningioma risk., Nature genetics.
[PubMed 21804547]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55197
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter
US Server
