Description: Homo sapiens olfactory receptor, family 13, subfamily A, member 1 (OR13A1), mRNA. RefSeq Summary (NM_001004297): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr10:45,798,806-45,803,015 Size: 4,210 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr10:45,798,884-45,799,858 Size: 975 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q8NGR1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007608 sensory perception of smell GO:0050896 response to stimulus GO:0050911 detection of chemical stimulus involved in sensory perception of smell
AK131555 - Homo sapiens cDNA FLJ16797 fis, clone TESTI2043585, weakly similar to Olfactory receptor 5V1. LP895796 - Sequence 660 from Patent EP3253886. BC104855 - Homo sapiens olfactory receptor, family 13, subfamily A, member 1, mRNA (cDNA clone MGC:132515 IMAGE:8143858), complete cds. BC143622 - Homo sapiens olfactory receptor, family 13, subfamily A, member 1, mRNA (cDNA clone MGC:177152 IMAGE:9052135), complete cds. BC104853 - Homo sapiens olfactory receptor, family 13, subfamily A, member 1, mRNA (cDNA clone MGC:132513 IMAGE:8143856), complete cds. KJ899532 - Synthetic construct Homo sapiens clone ccsbBroadEn_08926 OR13A1 gene, encodes complete protein. AB463955 - Synthetic construct DNA, clone: pF1KB7137, Homo sapiens OR13A1 gene for olfactory receptor, family 13, subfamily A, member 1, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04740 - Olfactory transduction
Reactome (by CSHL, EBI, and GO)
Protein Q8NGR1 (Reactome details) participates in the following event(s):