Description: Homo sapiens tolloid-like 2 (TLL2), mRNA. RefSeq Summary (NM_012465): This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr10:98,124,363-98,273,683 Size: 149,321 Total Exon Count: 21 Strand: - Coding Region Position: hg19 chr10:98,127,845-98,273,442 Size: 145,598 Coding Exon Count: 21
ADHD | attention-deficit hyperactivity disorder Lesch ,et al. 2008, Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies, Journal of neural transmission (Vienna, Austria : 1996) 2008 115- 11 : 1573-85.
[PubMed 18839057]
Attention Deficit Disorder with Hyperactivity Klaus-Peter Lesch et al. Journal of neural transmission (Vienna, Austria : 1996) 2008, Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies., Journal of neural transmission (Vienna, Austria : 1996).
[PubMed 18839057]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6L7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
AB023149 - Homo sapiens KIAA0932 mRNA for KIAA0932 protein. BC112341 - Homo sapiens tolloid-like 2, mRNA (cDNA clone MGC:133312 IMAGE:40038720), complete cds. BC112366 - Homo sapiens tolloid-like 2, mRNA (cDNA clone MGC:133313 IMAGE:40038726), complete cds. AF059516 - Homo sapiens tolloid-like 2 protein (TLL2) mRNA, complete cds. BC113577 - Homo sapiens tolloid-like 2, mRNA (cDNA clone MGC:142137 IMAGE:8322629), complete cds. BC111599 - Synthetic construct Homo sapiens clone IMAGE:40080557, MGC:133420 TLL2 protein (TLL2) mRNA, encodes complete protein. AB384048 - Synthetic construct DNA, clone: pF1KSDA0932, Homo sapiens TLL2 gene for tolloid-like protein 2 precursor, complete cds, without stop codon, in Flexi system. BC013871 - Homo sapiens tolloid-like 2, mRNA (cDNA clone IMAGE:3836889), partial cds. BC030548 - Homo sapiens cDNA clone IMAGE:5182610, containing frame-shift errors. AK026106 - Homo sapiens cDNA: FLJ22453 fis, clone HRC09679, highly similar to AF059516 Homo sapiens tolloid-like 2 protein (TLL2) mRNA. JD053476 - Sequence 34500 from Patent EP1572962. JD508554 - Sequence 489578 from Patent EP1572962. JD504169 - Sequence 485193 from Patent EP1572962. JD504030 - Sequence 485054 from Patent EP1572962. JD553714 - Sequence 534738 from Patent EP1572962. JD501334 - Sequence 482358 from Patent EP1572962. JD062330 - Sequence 43354 from Patent EP1572962. JD276469 - Sequence 257493 from Patent EP1572962. JD050002 - Sequence 31026 from Patent EP1572962. JD350491 - Sequence 331515 from Patent EP1572962. JD504709 - Sequence 485733 from Patent EP1572962. JD300902 - Sequence 281926 from Patent EP1572962. JD166662 - Sequence 147686 from Patent EP1572962. JD251792 - Sequence 232816 from Patent EP1572962. JD418362 - Sequence 399386 from Patent EP1572962. JD339367 - Sequence 320391 from Patent EP1572962. JD083336 - Sequence 64360 from Patent EP1572962. JD176613 - Sequence 157637 from Patent EP1572962. JD424990 - Sequence 406014 from Patent EP1572962. JD496979 - Sequence 478003 from Patent EP1572962. JD177431 - Sequence 158455 from Patent EP1572962. JD501760 - Sequence 482784 from Patent EP1572962. JD453356 - Sequence 434380 from Patent EP1572962. JD303471 - Sequence 284495 from Patent EP1572962. JD436207 - Sequence 417231 from Patent EP1572962. JD245810 - Sequence 226834 from Patent EP1572962. JD475533 - Sequence 456557 from Patent EP1572962. JD424872 - Sequence 405896 from Patent EP1572962. JD480020 - Sequence 461044 from Patent EP1572962. JD432325 - Sequence 413349 from Patent EP1572962. JD483480 - Sequence 464504 from Patent EP1572962. JD112968 - Sequence 93992 from Patent EP1572962. JD131174 - Sequence 112198 from Patent EP1572962. JD273584 - Sequence 254608 from Patent EP1572962. JD520610 - Sequence 501634 from Patent EP1572962. JD304188 - Sequence 285212 from Patent EP1572962. JD188611 - Sequence 169635 from Patent EP1572962. JD048435 - Sequence 29459 from Patent EP1572962. JD094606 - Sequence 75630 from Patent EP1572962. CQ873774 - Sequence 193 from Patent WO2004076622. DD413611 - Regulation of Mammalian Cells. JD229442 - Sequence 210466 from Patent EP1572962. JD461696 - Sequence 442720 from Patent EP1572962. JD271692 - Sequence 252716 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y6L7 (Reactome details) participates in the following event(s):
R-HSA-3814820 HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 R-HSA-2214330 Cleavage of collagen VII NC2 region by BMP1 R-HSA-2002440 Removal of fibrillar collagen C-propeptides R-HSA-2022141 Prolysyl oxidase activation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-2214320 Anchoring fibril formation R-HSA-1650814 Collagen biosynthesis and modifying enzymes R-HSA-2243919 Crosslinking of collagen fibrils R-HSA-1474244 Extracellular matrix organization R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-1474290 Collagen formation