Description: Homo sapiens glutathione S-transferase omega 1 (GSTO1), transcript variant 1, mRNA. RefSeq Summary (NM_004832): The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr10:106,014,468-106,027,222 Size: 12,755 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr10:106,014,687-106,027,163 Size: 12,477 Coding Exon Count: 6
Alzheimer's Disease Li YJ et al 2003, Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease., Human molecular genetics. 2003 Dec;12(24):3259-67.
[PubMed 14570706]
Parkinson's disease Li YJ et al 2003, Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease., Human molecular genetics. 2003 Dec;12(24):3259-67.
[PubMed 14570706]
stroke; dementia Kolsch, H. et al. 2004, Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke., Neurology. 2004 Dec;63(12):2255-60.
[PubMed 15623683]
The GSTO1 Asp allele may be a genetic risk factor for cerebrovascular diseases, and might influence the course of Alzheimer disease, even though effects vary in different studies.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78417
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006749 glutathione metabolic process GO:0008152 metabolic process GO:0009407 toxin catabolic process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion GO:0019852 L-ascorbic acid metabolic process GO:0032259 methylation GO:0035722 interleukin-12-mediated signaling pathway GO:0042178 xenobiotic catabolic process GO:0055114 oxidation-reduction process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0071243 cellular response to arsenic-containing substance GO:0098869 cellular oxidant detoxification GO:1901687 glutathione derivative biosynthetic process
US Server
