Description: Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA. RefSeq Summary (NM_001025295): This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr11:298,201-299,526 Size: 1,326 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr11:298,501-299,490 Size: 990 Coding Exon Count: 2
ID:IFM5_HUMAN DESCRIPTION: RecName: Full=Interferon-induced transmembrane protein 5; AltName: Full=Bone-restricted interferon-induced transmembrane protein-like protein; Short=BRIL; AltName: Full=Dispanin subfamily A member 1; Short=DSPA1; FUNCTION: Plays a role in bone mineralization (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the CD225/Dispanin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04505 - Interferon-induced transmembrane protein
ModBase Predicted Comparative 3D Structure on A6NNB3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0001701 in utero embryonic development GO:0007275 multicellular organism development GO:0009607 response to biotic stimulus GO:0030282 bone mineralization GO:0030500 regulation of bone mineralization GO:0060349 bone morphogenesis