Description: Homo sapiens cysteinyl-tRNA synthetase (CARS1), transcript variant 3, mRNA. RefSeq Summary (NM_001014437): This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]. Transcript (Including UTRs) Position: hg19 chr11:3,022,152-3,078,681 Size: 56,530 Total Exon Count: 23 Strand: - Coding Region Position: hg19 chr11:3,022,344-3,078,597 Size: 56,254 Coding Exon Count: 23
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF01406 - tRNA synthetases class I (C) catalytic domain
SCOP Domains: 47266 - 4-helical cytokines 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 52374 - Nucleotidylyl transferase
ModBase Predicted Comparative 3D Structure on P49589-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
