Human Gene UEVLD (uc001mov.4)
  Description: Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD), transcript variant 4, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:18,552,950-18,610,293 Size: 57,344 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr11:18,554,019-18,610,201 Size: 56,183 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:18,552,950-18,610,293)mRNA (may differ from genome)Protein (357 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.97 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 206.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.9092-0.532 Picture PostScript Text
3' UTR -250.411069-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00056 - lactate/malate dehydrogenase, NAD binding domain
PF05743 - UEV domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like
54495 - UBC-like

ModBase Predicted Comparative 3D Structure on Q8IX04-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK000727 - Homo sapiens cDNA FLJ20720 fis, clone HEP16483, highly similar to AF004230 Homo sapiens monocyte/macrophage Ig-related receptor.
AK295501 - Homo sapiens cDNA FLJ61687 complete cds, highly similar to Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD), transcript variant 1, mRNA.
AF503350 - Homo sapiens putative ubiquitin-conjugating enzyme E2 variant mRNA, complete cds.
LF384274 - JP 2014500723-A/191777: Polycomb-Associated Non-Coding RNAs.
AK001930 - Homo sapiens cDNA FLJ11068 fis, clone PLACE1004918, weakly similar to L-LACTATE DEHYDROGENASE M CHAIN (EC 1.1.1.27).
BC064566 - Homo sapiens UEV and lactate/malate dehyrogenase domains, mRNA (cDNA clone MGC:74529 IMAGE:5576632), complete cds.
AK296835 - Homo sapiens cDNA FLJ54696 complete cds, highly similar to Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD), transcript variant 1, mRNA.
JD048317 - Sequence 29341 from Patent EP1572962.
JD504239 - Sequence 485263 from Patent EP1572962.
JD556743 - Sequence 537767 from Patent EP1572962.
AK301537 - Homo sapiens cDNA FLJ60924 complete cds, highly similar to Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD), transcript variant 1, mRNA.
LF367998 - JP 2014500723-A/175501: Polycomb-Associated Non-Coding RNAs.
AK316191 - Homo sapiens cDNA, FLJ79090 complete cds, highly similar to Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD), transcript variant 1, mRNA.
JD167336 - Sequence 148360 from Patent EP1572962.
JD379952 - Sequence 360976 from Patent EP1572962.
JD131363 - Sequence 112387 from Patent EP1572962.
JD499163 - Sequence 480187 from Patent EP1572962.
JD499430 - Sequence 480454 from Patent EP1572962.
AK314521 - Homo sapiens cDNA, FLJ95340, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2-like (UEV3), mRNA.
KJ902807 - Synthetic construct Homo sapiens clone ccsbBroadEn_12201 UEVLD gene, encodes complete protein.
LF368003 - JP 2014500723-A/175506: Polycomb-Associated Non-Coding RNAs.
LF368004 - JP 2014500723-A/175507: Polycomb-Associated Non-Coding RNAs.
BC011011 - Homo sapiens UEV and lactate/malate dehyrogenase domains, mRNA (cDNA clone IMAGE:4286315), complete cds.
CU679872 - Synthetic construct Homo sapiens gateway clone IMAGE:100017552 5' read UEVLD mRNA.
KJ902806 - Synthetic construct Homo sapiens clone ccsbBroadEn_12200 UEVLD gene, encodes complete protein.
MA619851 - JP 2018138019-A/191777: Polycomb-Associated Non-Coding RNAs.
MA603575 - JP 2018138019-A/175501: Polycomb-Associated Non-Coding RNAs.
MA603580 - JP 2018138019-A/175506: Polycomb-Associated Non-Coding RNAs.
MA603581 - JP 2018138019-A/175507: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001261383, NP_001248312, Q8IX04-3, uc001mov.3, UEV3
UCSC ID: uc001mov.4
RefSeq Accession: NM_001261383
Protein: Q8IX04-3, splice isoform of Q8IX04 CCDS: CCDS58123.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001261383.1
exon count: 10CDS single in 3' UTR: no RNA size: 2235
ORF size: 1074CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1742.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.