Description: Homo sapiens formin binding protein 4 (FNBP4), mRNA. RefSeq Summary (NM_015308): This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]. Transcript (Including UTRs) Position: hg19 chr11:47,738,069-47,788,664 Size: 50,596 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr11:47,738,974-47,786,855 Size: 47,882 Coding Exon Count: 16
ID:FNBP4_HUMAN DESCRIPTION: RecName: Full=Formin-binding protein 4; AltName: Full=Formin-binding protein 30; SUBUNIT: Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro- rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding. DOMAIN: These WW domains interact with Arg/Gly-rich-flanked Pro- rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 2 WW domains. SEQUENCE CAUTION: Sequence=BAA76858.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N3X1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
