ID:BATF2_HUMAN DESCRIPTION: RecName: Full=Basic leucine zipper transcriptional factor ATF-like 2; Short=B-ATF-2; AltName: Full=Suppressor of AP-1 regulated by IFN; Short=SARI; FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates to the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). SUBUNIT: Heterodimer; heterodimerizes with JUN family proteins (By similarity). INTERACTION: Q15038:DAZAP2; NbExp=3; IntAct=EBI-742695, EBI-724310; P17275:JUNB; NbExp=3; IntAct=EBI-742695, EBI-748062; SUBCELLULAR LOCATION: Nucleus (By similarity). INDUCTION: By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level). SIMILARITY: Belongs to the bZIP family. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N1L9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0030154 cell differentiation GO:0042832 defense response to protozoan GO:0043011 myeloid dendritic cell differentiation
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