Description: Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA. RefSeq Summary (NM_005125): Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr11:66,360,690-66,373,490 Size: 12,801 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr11:66,360,733-66,373,326 Size: 12,594 Coding Exon Count: 8
ID:CCS_HUMAN DESCRIPTION: RecName: Full=Copper chaperone for superoxide dismutase; AltName: Full=Superoxide dismutase copper chaperone; FUNCTION: Delivers copper to copper zinc superoxide dismutase (SOD1). COFACTOR: Binds 2 copper ions per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. PTM: Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241. SIMILARITY: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. SIMILARITY: Contains 1 HMA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14618
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006801 superoxide metabolic process GO:0015680 intracellular copper ion transport GO:0019430 removal of superoxide radicals GO:0030001 metal ion transport GO:0034599 cellular response to oxidative stress GO:0051353 positive regulation of oxidoreductase activity GO:0055114 oxidation-reduction process