Description: Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA. RefSeq Summary (NM_198896): This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr11:73,386,683-73,472,201 Size: 85,519 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr11:73,388,943-73,471,680 Size: 82,738 Coding Exon Count: 8
ID:RAB6A_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-6A; Short=Rab-6; FUNCTION: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. SUBUNIT: Interacts with CCDC64; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. INTERACTION: Q8IWJ2:GCC2; NbExp=4; IntAct=EBI-1052826, EBI-1645320; SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF00071 - Ras family PF01926 - 50S ribosome-binding GTPase PF04670 - Gtr1/RagA G protein conserved region PF08477 - Ras of Complex, Roc, domain of DAPkinase PF09439 - Signal recognition particle receptor beta subunit
ModBase Predicted Comparative 3D Structure on P20340
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0015031 protein transport GO:0016032 viral process GO:0016192 vesicle-mediated transport GO:0018125 peptidyl-cysteine methylation GO:0019882 antigen processing and presentation GO:0034067 protein localization to Golgi apparatus GO:0034498 early endosome to Golgi transport GO:0043312 neutrophil degranulation GO:0072385 minus-end-directed organelle transport along microtubule
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