Description: Homo sapiens diacylglycerol O-acyltransferase 2 (DGAT2), transcript variant 1, mRNA. RefSeq Summary (NM_032564): This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr11:75,479,778-75,512,581 Size: 32,804 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr11:75,480,037-75,511,553 Size: 31,517 Coding Exon Count: 8
ID:DGAT2_HUMAN DESCRIPTION: RecName: Full=Diacylglycerol O-acyltransferase 2; EC=2.3.1.20; AltName: Full=Acyl-CoA retinol O-fatty-acyltransferase; Short=ARAT; Short=Retinol O-fatty-acyltransferase; EC=2.3.1.76; AltName: Full=Diglyceride acyltransferase 2; FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). CATALYTIC ACTIVITY: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. CATALYTIC ACTIVITY: Acyl-CoA + retinol = CoA + retinyl ester. ENZYME REGULATION: Inhibited by niacin (By similarity). PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. SUBUNIT: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity). TISSUE SPECIFICITY: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. SIMILARITY: Belongs to the diacylglycerol acyltransferase family. SEQUENCE CAUTION: Sequence=BAD38635.1; Type=Erroneous initiation; Sequence=CAD38961.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96PD7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.