Description: Homo sapiens glutamate receptor, ionotropic, AMPA 4 (GRIA4), transcript variant 3, mRNA. RefSeq Summary (NM_001077244): Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr11:105,480,800-105,784,231 Size: 303,432 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr11:105,481,725-105,782,634 Size: 300,910 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF01094 - Receptor family ligand binding region
SCOP Domains: 53822 - Periplasmic binding protein-like I
ModBase Predicted Comparative 3D Structure on P48058-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction
Reactome (by CSHL, EBI, and GO)
Protein P48058 (Reactome details) participates in the following event(s):
R-HSA-420977 Ca permeable AMPA receptor ligand binding R-HSA-399712 Activation of Ca permeable AMPA receptors R-HSA-416320 Trafficking of GluR1-containing AMPA receptors R-HSA-420980 Activation of Ca permeable AMPA receptors R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse R-HSA-420975 Ca impermeable AMPA receptor ligand binding R-HSA-438037 Membrane depolarization upon activation of Ca impermeable AMPA receptors R-HSA-399711 Activation of Ca impermeable AMPA receptors R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors R-HSA-8849881 SALM2 associate with AMPA and NMDA receptors R-HSA-432162 Unblocking of NMDA receptor R-HSA-399710 Activation of AMPA receptors R-HSA-399719 Trafficking of AMPA receptors R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-8849932 Synaptic adhesion-like molecules R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-442755 Activation of NMDA receptor and postsynaptic events R-HSA-6794362 Protein-protein interactions at synapses R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112316 Neuronal System R-HSA-112315 Transmission across Chemical Synapses
US Server
