Human Gene PRMT8 (uc001qmh.3)
  Description: Homo sapiens protein arginine methyltransferase 8 (PRMT8), transcript variant 2, mRNA.
RefSeq Summary (NM_001256536): Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr12:3,701,390-3,703,138 Size: 1,749 Total Exon Count: 2 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:3,701,390-3,703,138)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerH-INVHGNCLynxPubMed
Treefam

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRMT8
CDC HuGE Published Literature: PRMT8
Positive Disease Associations: Cell Adhesion Molecules , HDL cholesterol
Related Studies:
  1. Cell Adhesion Molecules
    , , . [PubMed 0]
  2. HDL cholesterol
    Aulchenko ,et al. 2008, Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts, Nature genetics 2009 41- 1 : 47-55. [PubMed 19060911]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.29 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 84.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK315619 - Homo sapiens cDNA, FLJ96700, highly similar to Homo sapiens HMT1 hnRNP methyltransferase-like 4 (S. cerevisiae)(HRMT1L4), mRNA.
AB209027 - Homo sapiens mRNA for Protein arginine N-methyltransferase 4 variant protein.
BC022458 - Homo sapiens protein arginine methyltransferase 8, mRNA (cDNA clone MGC:26069 IMAGE:4796524), complete cds.
AB590500 - Synthetic construct DNA, clone: pFN21AE1873, Homo sapiens PRMT8 gene for protein arginine methyltransferase 8, without stop codon, in Flexi system.
AK026786 - Homo sapiens cDNA: FLJ23133 fis, clone LNG08560.
AF263539 - Homo sapiens arginine N-methyltransferase (HRMT1L3) mRNA, complete cds.
DQ892381 - Synthetic construct clone IMAGE:100005011; FLH185782.01X; RZPDo839E12148D protein arginine methyltransferase 8 (PRMT8) gene, encodes complete protein.
DQ895593 - Synthetic construct Homo sapiens clone IMAGE:100010053; FLH185778.01L; RZPDo839E12147D protein arginine methyltransferase 8 (PRMT8) gene, encodes complete protein.
KJ902909 - Synthetic construct Homo sapiens clone ccsbBroadEn_12303 PRMT8 gene, encodes complete protein.
AK093651 - Homo sapiens cDNA FLJ36332 fis, clone THYMU2006098, highly similar to Homo sapiens arginine N-methyltransferase (HRMT1L3) mRNA.
JD196623 - Sequence 177647 from Patent EP1572962.
JD092826 - Sequence 73850 from Patent EP1572962.
JD389160 - Sequence 370184 from Patent EP1572962.
JD316636 - Sequence 297660 from Patent EP1572962.
JD132332 - Sequence 113356 from Patent EP1572962.
JD398238 - Sequence 379262 from Patent EP1572962.
JD287407 - Sequence 268431 from Patent EP1572962.
JD176995 - Sequence 158019 from Patent EP1572962.
JD286170 - Sequence 267194 from Patent EP1572962.
JD150062 - Sequence 131086 from Patent EP1572962.
JD144425 - Sequence 125449 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK026786
UCSC ID: uc001qmh.3
RefSeq Accession: NM_001256536

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AK026786.1
exon count: 2CDS single in 3' UTR: no RNA size: 2606
ORF size: 0CDS single in intron: no Alignment % ID: 99.81
txCdsPredict score: 446.50frame shift in genome: no % Coverage: 38.49
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 7# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.