Human Gene RIMKLB (uc001quw.2)
Description: Homo sapiens ribosomal modification protein rimK-like family member B (RIMKLB), mRNA.
Transcript (Including UTRs)
Position: hg19 chr12:8,850,518-8,930,398 Size: 79,881 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr12:8,866,463-8,930,266 Size: 63,804 Coding Exon Count: 6
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D000082
Acetaminophen
D001151
Arsenic
D005557
Formaldehyde
C517826
tetrabrominated diphenyl ether 47
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF02655 - ATP-grasp domain
PF02955 - Prokaryotic glutathione synthetase, ATP-grasp domain
PF08443 - RimK-like ATP-grasp domain
SCOP Domains: 56059 - Glutathione synthetase ATP-binding domain-like
ModBase Predicted Comparative 3D Structure on Q9ULI2-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
BC033793 - Homo sapiens ribosomal modification protein rimK-like family member B, mRNA (cDNA clone MGC:45396 IMAGE:5139256), complete cds.AK302847 - Homo sapiens cDNA FLJ58713 complete cds.BC006368 - Homo sapiens family with sequence similarity 80, member B, mRNA (cDNA clone IMAGE:4131990).AB033064 - Homo sapiens KIAA1238 mRNA for KIAA1238 protein.AB385440 - Synthetic construct DNA, clone: pF1KA1238, Homo sapiens FAM80B gene for ribosomal protein S6 modification-like protein B, complete cds, without stop codon, in Flexi system.KJ902958 - Synthetic construct Homo sapiens clone ccsbBroadEn_12352 RIMKLB gene, encodes complete protein.BC021977 - Homo sapiens ribosomal modification protein rimK-like family member B, mRNA (cDNA clone IMAGE:3951537), partial cds.JD181281 - Sequence 162305 from Patent EP1572962.JD462741 - Sequence 443765 from Patent EP1572962.JD052321 - Sequence 33345 from Patent EP1572962.JD373628 - Sequence 354652 from Patent EP1572962.CU689744 - Synthetic construct Homo sapiens gateway clone IMAGE:100016686 5' read FAM80B mRNA.AK311171 - Homo sapiens cDNA, FLJ18213.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q9ULI2 (Reactome details) participates in the following event(s):R-HSA-8942575 N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism
Other Names for This Gene
Alternate Gene Symbols: BC006368, FAM80B, KIAA1238, NM_020734, NP_065785, Q9ULI2-2UCSC ID: uc001quw.2RefSeq Accession: NM_020734
Protein: Q9ULI2-2 , splice isoform of Q9ULI2
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
BC006368.2
exon count:
8 CDS single in 3' UTR:
no
RNA size:
2044
ORF size:
924 CDS single in intron:
no
Alignment % ID:
99.95
txCdsPredict score:
1854.50 frame shift in genome:
no
% Coverage:
99.22
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.