Human Gene FKBP11 (uc001rsp.3)
  Description: Homo sapiens FK506 binding protein 11, 19 kDa (FKBP11), transcript variant 1, mRNA.
RefSeq Summary (NM_016594): FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr12:49,315,742-49,319,330 Size: 3,589 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr12:49,315,767-49,319,211 Size: 3,445 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:49,315,742-49,319,330)mRNA (may differ from genome)Protein (201 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKB11_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP11; Short=PPIase FKBP11; EC=5.2.1.8; AltName: Full=19 kDa FK506-binding protein; Short=19 kDa FKBP; Short=FKBP-19; AltName: Full=FK506-binding protein 11; Short=FKBP-11; AltName: Full=Rotamase; Flags: Precursor;
FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the FKBP-type PPIase family.
SIMILARITY: Contains 1 PPIase FKBP-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.95 RPKM in Pancreas
Total median expression: 400.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.90119-0.386 Picture PostScript Text
3' UTR 0.00250.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase

SCOP Domains:
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on Q9NYL4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005528 FK506 binding
GO:0016853 isomerase activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0061077 chaperone-mediated protein folding

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB209018 - Homo sapiens mRNA for FK506 binding protein precursor variant protein.
AF238079 - Homo sapiens FK506 binding protein precursor (FKBP19) mRNA, complete cds.
AY358998 - Homo sapiens clone DNA49143 FKBP11 (UNQ336) mRNA, complete cds.
BC048292 - Homo sapiens FK506 binding protein 11, 19 kDa, mRNA (cDNA clone MGC:54182 IMAGE:5207367), complete cds.
LF210430 - JP 2014500723-A/17933: Polycomb-Associated Non-Coding RNAs.
AK094876 - Homo sapiens cDNA FLJ37557 fis, clone BRCAN2028634.
BC027973 - Homo sapiens FK506 binding protein 11, 19 kDa, mRNA (cDNA clone MGC:34323 IMAGE:5229643), complete cds.
LF337870 - JP 2014500723-A/145373: Polycomb-Associated Non-Coding RNAs.
DQ892057 - Synthetic construct clone IMAGE:100004687; FLH182766.01X; RZPDo839B12140D FK506 binding protein 11, 19 kDa (FKBP11) gene, encodes complete protein.
KJ893882 - Synthetic construct Homo sapiens clone ccsbBroadEn_03276 FKBP11 gene, encodes complete protein.
DQ895251 - Synthetic construct Homo sapiens clone IMAGE:100009711; FLH182762.01L; RZPDo839B12139D FK506 binding protein 11, 19 kDa (FKBP11) gene, encodes complete protein.
LF337871 - JP 2014500723-A/145374: Polycomb-Associated Non-Coding RNAs.
AK301455 - Homo sapiens cDNA FLJ53772 complete cds, highly similar to FK506-binding protein 11 precursor (EC 5.2.1.8).
MA446007 - JP 2018138019-A/17933: Polycomb-Associated Non-Coding RNAs.
MA573447 - JP 2018138019-A/145373: Polycomb-Associated Non-Coding RNAs.
MA573448 - JP 2018138019-A/145374: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DWB7, FKB11_HUMAN, FKBP19, NM_016594, NP_057678, Q9NYL4, UNQ336/PRO535
UCSC ID: uc001rsp.3
RefSeq Accession: NM_016594
Protein: Q9NYL4 (aka FKB11_HUMAN or FK11_HUMAN)
CCDS: CCDS8773.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_016594.2
exon count: 6CDS single in 3' UTR: no RNA size: 767
ORF size: 606CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1412.00frame shift in genome: no % Coverage: 97.78
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.