Description: Homo sapiens keratin 78 (KRT78), mRNA. RefSeq Summary (NM_173352): This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:53,232,746-53,242,778 Size: 10,033 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr12:53,232,897-53,242,714 Size: 9,818 Coding Exon Count: 9
ID:K2C78_HUMAN DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 78; AltName: Full=Cytokeratin-78; Short=CK-78; AltName: Full=Keratin-5b; AltName: Full=Keratin-78; Short=K78; AltName: Full=Type-II keratin Kb40; SUBUNIT: Heterotetramer of two type I and two type II keratins. TISSUE SPECIFICITY: Expressed in tongue, but not in skin or in any other tissues or organs examined. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40- 55 and 56-70 kDa, respectively). SIMILARITY: Belongs to the intermediate filament family. SEQUENCE CAUTION: Sequence=DAA00377.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein PF16208 - Keratin type II head
ModBase Predicted Comparative 3D Structure on Q8N1N4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.