Human Gene TMBIM4 (uc001stc.3)
Description: Homo sapiens transmembrane BAX inhibitor motif containing 4 (TMBIM4), mRNA.
Transcript (Including UTRs)
Position: hg19 chr12:66,530,717-66,563,807 Size: 33,091 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr12:66,531,740-66,563,731 Size: 31,992 Coding Exon Count: 7
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: LFG4_HUMAN
DESCRIPTION: RecName: Full=Protein lifeguard 4; AltName: Full=Golgi anti-apoptotic protein; AltName: Full=Protein S1R; AltName: Full=Transmembrane BAX inhibitor motif-containing protein 4; AltName: Full=Z-protein;
FUNCTION: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.SUBUNIT: Interacts with ITPR3.SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.SIMILARITY: Belongs to the BI1 family. LFG subfamily.SEQUENCE CAUTION: Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006214 - Bax_inhibitor_1-related
Pfam Domains: PF01027 - Inhibitor of apoptosis-promoting Bax1
ModBase Predicted Comparative 3D Structure on Q9HC24
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK301359 - Homo sapiens cDNA FLJ57212 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 4.AL117550 - Homo sapiens mRNA; cDNA DKFZp586H2223 (from clone DKFZp586H2223).AK225158 - Homo sapiens mRNA for hypothetical protein LOC51643 variant, clone: CBR03471.AF151877 - Homo sapiens CGI-119 protein mRNA, complete cds.AF113127 - Homo sapiens S1R protein (S1R) mRNA, complete cds.JD447294 - Sequence 428318 from Patent EP1572962.JD323073 - Sequence 304097 from Patent EP1572962.JD307190 - Sequence 288214 from Patent EP1572962.JD435032 - Sequence 416056 from Patent EP1572962.JD529791 - Sequence 510815 from Patent EP1572962.JD472537 - Sequence 453561 from Patent EP1572962.JD065941 - Sequence 46965 from Patent EP1572962.JD346144 - Sequence 327168 from Patent EP1572962.JD079661 - Sequence 60685 from Patent EP1572962.JD243267 - Sequence 224291 from Patent EP1572962.JD136235 - Sequence 117259 from Patent EP1572962.JD050366 - Sequence 31390 from Patent EP1572962.AK094572 - Homo sapiens cDNA FLJ37253 fis, clone BRAMY2007594.JD561228 - Sequence 542252 from Patent EP1572962.JD327693 - Sequence 308717 from Patent EP1572962.JD413349 - Sequence 394373 from Patent EP1572962.JD198058 - Sequence 179082 from Patent EP1572962.JD246861 - Sequence 227885 from Patent EP1572962.JD413350 - Sequence 394374 from Patent EP1572962.JD198059 - Sequence 179083 from Patent EP1572962.JD212679 - Sequence 193703 from Patent EP1572962.JD542716 - Sequence 523740 from Patent EP1572962.JD537271 - Sequence 518295 from Patent EP1572962.JD198057 - Sequence 179081 from Patent EP1572962.JD212678 - Sequence 193702 from Patent EP1572962.JD542715 - Sequence 523739 from Patent EP1572962.JD246859 - Sequence 227883 from Patent EP1572962.JD413347 - Sequence 394371 from Patent EP1572962.JD098844 - Sequence 79868 from Patent EP1572962.JD501921 - Sequence 482945 from Patent EP1572962.JD048793 - Sequence 29817 from Patent EP1572962.AF182041 - Homo sapiens z-protein mRNA, complete cds.AF182414 - Homo sapiens MDS013 (MDS013) mRNA, complete cds.BC070366 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6614308).AK127285 - Homo sapiens cDNA FLJ45352 fis, clone BRHIP3012185.AK075069 - Homo sapiens cDNA FLJ90588 fis, clone PLACE1000927, moderately similar to Z-protein.BC004401 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:3636667), complete cds.AF161526 - Homo sapiens HSPC178 mRNA, complete cds.JD092586 - Sequence 73610 from Patent EP1572962.BC020613 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:4273952).BC052273 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6647551).BC094852 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6568839), containing frame-shift errors.BC156584 - Synthetic construct Homo sapiens clone IMAGE:100062079, MGC:190166 transmembrane BAX inhibitor motif containing 4 (TMBIM4) mRNA, encodes complete protein.BC148528 - Synthetic construct Homo sapiens clone IMAGE:100015508, MGC:183068 transmembrane BAX inhibitor motif containing 4 (TMBIM4) mRNA, encodes complete protein.AB464309 - Synthetic construct DNA, clone: pF1KB7437, Homo sapiens TMBIM4 gene for transmembrane BAX inhibitor motif containing protein 4, without stop codon, in Flexi system.JD023804 - Sequence 4828 from Patent EP1572962.KJ902609 - Synthetic construct Homo sapiens clone ccsbBroadEn_12003 TMBIM4 gene, encodes complete protein.
Other Names for This Gene
Alternate Gene Symbols: CGI-119, GAAP, LFG4, LFG4_HUMAN, NM_016056, NP_057140, Q542Z6, Q9HC24, Q9UHY5, Q9Y3C2UCSC ID: uc001stc.3RefSeq Accession: NM_016056
Protein: Q9HC24
(aka LFG4_HUMAN)
CCDS: CCDS41805.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_016056.2
exon count:
7 CDS single in 3' UTR:
no
RNA size:
1831
ORF size:
717 CDS single in intron:
no
Alignment % ID:
99.89
txCdsPredict score:
1634.00 frame shift in genome:
no
% Coverage:
99.18
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.