Human Gene TMBIM4 (uc001std.3)
  Description: Homo sapiens transmembrane BAX inhibitor motif containing 4 (TMBIM4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:66,530,717-66,563,807 Size: 33,091 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr12:66,531,740-66,563,676 Size: 31,937 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:66,530,717-66,563,807)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIPubMed
TreefamUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMBIM4
Diseases sorted by gene-association score: venezuelan hemorrhagic fever (5), lassa fever (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.59 RPKM in Testis
Total median expression: 135.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.10131-0.512 Picture PostScript Text
3' UTR -259.631023-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006214 - Bax_inhibitor_1-related

Pfam Domains:
PF01027 - Inhibitor of apoptosis-promoting Bax1

ModBase Predicted Comparative 3D Structure on G3V1M2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK301359 - Homo sapiens cDNA FLJ57212 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 4.
AL117550 - Homo sapiens mRNA; cDNA DKFZp586H2223 (from clone DKFZp586H2223).
AK225158 - Homo sapiens mRNA for hypothetical protein LOC51643 variant, clone: CBR03471.
AF151877 - Homo sapiens CGI-119 protein mRNA, complete cds.
AF113127 - Homo sapiens S1R protein (S1R) mRNA, complete cds.
JD447294 - Sequence 428318 from Patent EP1572962.
JD323073 - Sequence 304097 from Patent EP1572962.
JD307190 - Sequence 288214 from Patent EP1572962.
JD435032 - Sequence 416056 from Patent EP1572962.
JD529791 - Sequence 510815 from Patent EP1572962.
JD472537 - Sequence 453561 from Patent EP1572962.
JD065941 - Sequence 46965 from Patent EP1572962.
JD346144 - Sequence 327168 from Patent EP1572962.
JD079661 - Sequence 60685 from Patent EP1572962.
JD243267 - Sequence 224291 from Patent EP1572962.
JD136235 - Sequence 117259 from Patent EP1572962.
JD050366 - Sequence 31390 from Patent EP1572962.
AK094572 - Homo sapiens cDNA FLJ37253 fis, clone BRAMY2007594.
JD561228 - Sequence 542252 from Patent EP1572962.
JD327693 - Sequence 308717 from Patent EP1572962.
JD413349 - Sequence 394373 from Patent EP1572962.
JD198058 - Sequence 179082 from Patent EP1572962.
JD246861 - Sequence 227885 from Patent EP1572962.
JD413350 - Sequence 394374 from Patent EP1572962.
JD198059 - Sequence 179083 from Patent EP1572962.
JD212679 - Sequence 193703 from Patent EP1572962.
JD542716 - Sequence 523740 from Patent EP1572962.
JD537271 - Sequence 518295 from Patent EP1572962.
JD198057 - Sequence 179081 from Patent EP1572962.
JD212678 - Sequence 193702 from Patent EP1572962.
JD542715 - Sequence 523739 from Patent EP1572962.
JD246859 - Sequence 227883 from Patent EP1572962.
JD413347 - Sequence 394371 from Patent EP1572962.
JD098844 - Sequence 79868 from Patent EP1572962.
JD501921 - Sequence 482945 from Patent EP1572962.
JD048793 - Sequence 29817 from Patent EP1572962.
AF182041 - Homo sapiens z-protein mRNA, complete cds.
AF182414 - Homo sapiens MDS013 (MDS013) mRNA, complete cds.
BC070366 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6614308).
AK127285 - Homo sapiens cDNA FLJ45352 fis, clone BRHIP3012185.
AK075069 - Homo sapiens cDNA FLJ90588 fis, clone PLACE1000927, moderately similar to Z-protein.
BC004401 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:3636667), complete cds.
AF161526 - Homo sapiens HSPC178 mRNA, complete cds.
JD092586 - Sequence 73610 from Patent EP1572962.
BC020613 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:4273952).
BC052273 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6647551).
BC094852 - Homo sapiens transmembrane BAX inhibitor motif containing 4, mRNA (cDNA clone IMAGE:6568839), containing frame-shift errors.
BC156584 - Synthetic construct Homo sapiens clone IMAGE:100062079, MGC:190166 transmembrane BAX inhibitor motif containing 4 (TMBIM4) mRNA, encodes complete protein.
BC148528 - Synthetic construct Homo sapiens clone IMAGE:100015508, MGC:183068 transmembrane BAX inhibitor motif containing 4 (TMBIM4) mRNA, encodes complete protein.
AB464309 - Synthetic construct DNA, clone: pF1KB7437, Homo sapiens TMBIM4 gene for transmembrane BAX inhibitor motif containing protein 4, without stop codon, in Flexi system.
JD023804 - Sequence 4828 from Patent EP1572962.
KJ902609 - Synthetic construct Homo sapiens clone ccsbBroadEn_12003 TMBIM4 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: BC004401, G3V1M2, G3V1M2_HUMAN, hCG_16706
UCSC ID: uc001std.3
RefSeq Accession: NM_016056
Protein: G3V1M2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC004401.1
exon count: 7CDS single in 3' UTR: no RNA size: 909
ORF size: 624CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 1393.00frame shift in genome: no % Coverage: 96.37
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.