Description: Homo sapiens epiphycan (EPYC), mRNA. RefSeq Summary (NM_004950): Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:91,357,456-91,398,803 Size: 41,348 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr12:91,357,933-91,396,342 Size: 38,410 Coding Exon Count: 6
ID:EPYC_HUMAN DESCRIPTION: RecName: Full=Epiphycan; AltName: Full=Dermatan sulfate proteoglycan 3; AltName: Full=Proteoglycan-Lb; Short=PG-Lb; AltName: Full=Small chondroitin/dermatan sulfate proteoglycan; Flags: Precursor; FUNCTION: May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Cartilage, ligament, and placenta. PTM: The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity). SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. SIMILARITY: Contains 6 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRNT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q99645
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.