Description: Homo sapiens chronic lymphocytic leukemia up-regulated 1 (CLLU1), transcript variant 2, non-coding RNA. RefSeq Summary (NR_027932): Expression of this gene has been shown to be upregulated in some individuals with chronic lymphocytic leukemia (CLL), and has been used for prognostic and diagnostic purposes. This gene was originally identified as a human-specific putative protein-coding gene due to the presence of a peptide (PAp00140670, HIIYSTFLSK) that could have supported translation at this locus. This peptide is not present in more recent builds of PeptideAtlas, and the presence of a protein product at this locus has not been independently verified. For this reason, this gene is being represented as non-coding. Sequence comparisons to other primates indicates that no other primate is predicted to contain an open reading frame. [provided by RefSeq, Feb 2017]. Transcript (Including UTRs) Position: hg19 chr12:92,815,307-92,824,778 Size: 9,472 Total Exon Count: 3 Strand: +
Death, Sudden, Cardiac Bradley E Aouizerat et al. BMC cardiovascular disorders 2012, GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease., BMC cardiovascular disorders.
[PubMed 21658281]
We demonstrate 11 gene associations for sudden cardiac arrest due to ventricular tachycardia/ventricular fibrillation in patients with coronary artery disease. Validation studies in independent cohorts and functional studies are required to confirm these associations.
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AJ845167 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 6. AJ845163 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 2. CQ819405 - Sequence 6 from Patent WO2004046376. CQ819406 - Sequence 7 from Patent WO2004046376. CQ819410 - Sequence 11 from Patent WO2004046376. AJ845162 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 1. AJ845164 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 3. CQ819407 - Sequence 8 from Patent WO2004046376. CQ819418 - Sequence 19 from Patent WO2004046376. CQ819403 - Sequence 4 from Patent WO2004046376. CQ819419 - Sequence 20 from Patent WO2004046376. AJ845166 - Homo sapiens mRNA for CLLU1 protein (CLLU1 gene), splice variant 5. AJ845165 - Homo sapiens mRNA for CLLU1 protein (CLLU1 gene), splice variant 4. CQ819409 - Sequence 10 from Patent WO2004046376. CQ819401 - Sequence 2 from Patent WO2004046376. CQ819420 - Sequence 21 from Patent WO2004046376. CQ819421 - Sequence 22 from Patent WO2004046376. CQ819422 - Sequence 23 from Patent WO2004046376.