Human Gene CLLU1 (uc001tcc.2)
  Description: Homo sapiens chronic lymphocytic leukemia up-regulated 1 (CLLU1), transcript variant 2, non-coding RNA.
RefSeq Summary (NR_027932): Expression of this gene has been shown to be upregulated in some individuals with chronic lymphocytic leukemia (CLL), and has been used for prognostic and diagnostic purposes. This gene was originally identified as a human-specific putative protein-coding gene due to the presence of a peptide (PAp00140670, HIIYSTFLSK) that could have supported translation at this locus. This peptide is not present in more recent builds of PeptideAtlas, and the presence of a protein product at this locus has not been independently verified. For this reason, this gene is being represented as non-coding. Sequence comparisons to other primates indicates that no other primate is predicted to contain an open reading frame. [provided by RefSeq, Feb 2017].
Transcript (Including UTRs)
   Position: hg19 chr12:92,815,307-92,824,778 Size: 9,472 Total Exon Count: 3 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:92,815,307-92,824,778)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerHGNCLynxMalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CLLU1
CDC HuGE Published Literature: CLLU1
Positive Disease Associations: Death, Sudden, Cardiac , Prostatic Neoplasms
Related Studies:
  1. Death, Sudden, Cardiac
    Bradley E Aouizerat et al. BMC cardiovascular disorders 2012, GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease., BMC cardiovascular disorders. [PubMed 21658281]
    We demonstrate 11 gene associations for sudden cardiac arrest due to ventricular tachycardia/ventricular fibrillation in patients with coronary artery disease. Validation studies in independent cohorts and functional studies are required to confirm these associations.
  2. Prostatic Neoplasms
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: CLLU1
Diseases sorted by gene-association score: chronic lymphocytic leukemia (25), leukemia (13)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.11 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 0.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AJ845167 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 6.
AJ845163 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 2.
CQ819405 - Sequence 6 from Patent WO2004046376.
CQ819406 - Sequence 7 from Patent WO2004046376.
CQ819410 - Sequence 11 from Patent WO2004046376.
AJ845162 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 1.
AJ845164 - Homo sapiens mRNA for non-coding transcript (CLLU1 gene), splice variant 3.
CQ819407 - Sequence 8 from Patent WO2004046376.
CQ819418 - Sequence 19 from Patent WO2004046376.
CQ819403 - Sequence 4 from Patent WO2004046376.
CQ819419 - Sequence 20 from Patent WO2004046376.
AJ845166 - Homo sapiens mRNA for CLLU1 protein (CLLU1 gene), splice variant 5.
AJ845165 - Homo sapiens mRNA for CLLU1 protein (CLLU1 gene), splice variant 4.
CQ819409 - Sequence 10 from Patent WO2004046376.
CQ819401 - Sequence 2 from Patent WO2004046376.
CQ819420 - Sequence 21 from Patent WO2004046376.
CQ819421 - Sequence 22 from Patent WO2004046376.
CQ819422 - Sequence 23 from Patent WO2004046376.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_027932
UCSC ID: uc001tcc.2
RefSeq Accession: NR_027932

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: NR_027932.1
exon count: 3CDS single in 3' UTR: no RNA size: 2831
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 24.50frame shift in genome: no % Coverage: 100.00
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.