Human Gene TMEM263 (uc001tmc.3)
  Description: Homo sapiens chromosome 12 open reading frame 23 (TMEM263), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:107,349,544-107,367,813 Size: 18,270 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:107,360,895-107,365,169 Size: 4,275 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:107,349,544-107,367,813)mRNA (may differ from genome)Protein (116 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHPRDLynxMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CL023_HUMAN
DESCRIPTION: RecName: Full=UPF0444 transmembrane protein C12orf23;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the UPF0444 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.07 RPKM in Cells - Cultured fibroblasts
Total median expression: 500.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.40306-0.541 Picture PostScript Text
3' UTR -639.162644-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15475 - Transmembrane protein C12orf23, UPF0444

ModBase Predicted Comparative 3D Structure on Q8WUH6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK024021 - Homo sapiens cDNA FLJ13959 fis, clone Y79AA1001228.
AK001731 - Homo sapiens cDNA FLJ10869 fis, clone NT2RP4001677.
BC020522 - Homo sapiens chromosome 12 open reading frame 23, mRNA (cDNA clone MGC:17943 IMAGE:3916886), complete cds.
AK022770 - Homo sapiens cDNA FLJ12708 fis, clone NT2RP1000943.
JD075880 - Sequence 56904 from Patent EP1572962.
JD414601 - Sequence 395625 from Patent EP1572962.
AK021783 - Homo sapiens cDNA FLJ11721 fis, clone HEMBA1005296.
HQ447937 - Synthetic construct Homo sapiens clone IMAGE:100071298; CCSB000819_01 chromosome 12 open reading frame 23 (C12orf23) gene, encodes complete protein.
KJ895123 - Synthetic construct Homo sapiens clone ccsbBroadEn_04517 C12orf23 gene, encodes complete protein.
JD348915 - Sequence 329939 from Patent EP1572962.
JD370148 - Sequence 351172 from Patent EP1572962.
JD503212 - Sequence 484236 from Patent EP1572962.
JD344941 - Sequence 325965 from Patent EP1572962.
JD225941 - Sequence 206965 from Patent EP1572962.
JD047067 - Sequence 28091 from Patent EP1572962.
JD359202 - Sequence 340226 from Patent EP1572962.
JD539548 - Sequence 520572 from Patent EP1572962.
AL117658 - Homo sapiens mRNA; cDNA DKFZp586H0924 (from clone DKFZp586H0924).
JD560465 - Sequence 541489 from Patent EP1572962.
JD364069 - Sequence 345093 from Patent EP1572962.
JD204458 - Sequence 185482 from Patent EP1572962.
JD562229 - Sequence 543253 from Patent EP1572962.
JD435742 - Sequence 416766 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK022770, B3KMN9, C12orf23, CL023_HUMAN, NM_152261, NP_689474, Q8WUH6
UCSC ID: uc001tmc.3
RefSeq Accession: NM_152261
Protein: Q8WUH6 (aka CL023_HUMAN)
CCDS: CCDS9110.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK022770.1
exon count: 3CDS single in 3' UTR: no RNA size: 3072
ORF size: 351CDS single in intron: no Alignment % ID: 99.84
txCdsPredict score: 902.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.