Description: Homo sapiens cyclin-dependent kinase 8 (CDK8), mRNA. RefSeq Summary (NM_001260): This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr13:26,828,756-26,978,569 Size: 149,814 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr13:26,828,779-26,978,218 Size: 149,440 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P49336-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC094784 - Homo sapiens cDNA clone IMAGE:30528795. BC069634 - Homo sapiens cyclin-dependent kinase 8, mRNA (cDNA clone MGC:97177 IMAGE:7262421), complete cds. BC104492 - Homo sapiens cyclin-dependent kinase 8, mRNA (cDNA clone MGC:126075 IMAGE:40032854), complete cds. BC105950 - Homo sapiens cyclin-dependent kinase 8, mRNA (cDNA clone MGC:126074 IMAGE:40032852), complete cds. BC107601 - Homo sapiens cyclin-dependent kinase 8, mRNA (cDNA clone MGC:126073 IMAGE:40032849), complete cds. X85753 - Homo sapiens mRNA for CDK8 protein kinase. CU686950 - Synthetic construct Homo sapiens gateway clone IMAGE:100022667 5' read CDK8 mRNA. KJ890887 - Synthetic construct Homo sapiens clone ccsbBroadEn_00281 CDK8 gene, encodes complete protein. KJ905168 - Synthetic construct Homo sapiens clone ccsbBroadEn_14578 CDK8 gene, encodes complete protein. AY702976 - Homo sapiens cyclin-dependent kinase 8 (CDK8) mRNA, complete cds, alternatively spliced. AK296875 - Homo sapiens cDNA FLJ56597 complete cds, highly similar to Cell division protein kinase 8 (EC 2.7.11.22). AK296084 - Homo sapiens cDNA FLJ56916 complete cds, highly similar to Cell division protein kinase 8 (EC 2.7.11.22). HG518164 - Homo sapiens mRNA for cyclin-dependent kinase 8 (CDK8 gene). L23208 - Human chromosome-specific mRNA. JD296829 - Sequence 277853 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
Reactome (by CSHL, EBI, and GO)
Protein P49336 (Reactome details) participates in the following event(s):
R-HSA-212352 Formation of ARC coactivator complex R-HSA-212380 Formation of TRAP coactivator complex R-HSA-212432 Formation of DRIP coactivator complex R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands R-HSA-1912393 MAML in complex with NICD1 recruits CDK8 R-NUL-2064916 MAML recruits CDK8:CCNC to xNICD1 R-HSA-2220957 NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC R-HSA-1912391 NICD1 is phosphorylated by CDK8 R-NUL-2065178 CDK8 phosphorylates xNICD1 R-HSA-2220971 CDK8 phosphorylates NICD1 PEST domain mutants R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-73857 RNA Polymerase II Transcription R-HSA-1266738 Developmental Biology R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-74160 Gene expression (Transcription) R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-1643685 Disease R-HSA-9006936 Signaling by TGF-beta family members
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