Human Gene EXOSC8 (uc001uvz.2)
  Description: Homo sapiens exosome component 8 (EXOSC8), mRNA.
RefSeq Summary (NM_181503): This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009].
Transcript (Including UTRs)
   Position: hg19 chr13:37,574,678-37,582,972 Size: 8,295 Total Exon Count: 11 Strand: +


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:37,574,678-37,582,972)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxMalacardsPubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EXOSC8
Diseases sorted by gene-association score: pontocerebellar hypoplasia, type 1c* (1300), pontocerebellar hypoplasia type 1* (175), pontocerebellar hypoplasia (10)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.60 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 407.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ898406 - Synthetic construct Homo sapiens clone ccsbBroadEn_07800 EXOSC8 gene, encodes complete protein.
AK096810 - Homo sapiens cDNA FLJ39491 fis, clone PROST2015924, weakly similar to Homo sapiens Opa-interacting protein OIP2 mRNA.
BC020773 - Homo sapiens exosome component 8, mRNA (cDNA clone MGC:22685 IMAGE:4808747), complete cds.
AL050353 - Homo sapiens mRNA; cDNA DKFZp564C0482 (from clone DKFZp564C0482).
AF279901 - Homo sapiens PNAS-147 mRNA, partial sequence.
AB463623 - Synthetic construct DNA, clone: pF1KB6391, Homo sapiens EXOSC8 gene for exosome component 8, without stop codon, in Flexi system.
DQ896414 - Synthetic construct Homo sapiens clone IMAGE:100010874; FLH194102.01L; RZPDo839F0669D exosome component 8 (EXOSC8) gene, encodes complete protein.
DQ893134 - Synthetic construct clone IMAGE:100005764; FLH194106.01X; RZPDo839F0679D exosome component 8 (EXOSC8) gene, encodes complete protein.
AF025438 - Homo sapiens Opa-interacting protein OIP2 mRNA, partial cds.
AK126602 - Homo sapiens cDNA FLJ44639 fis, clone BRACE2027382, highly similar to Homo sapiens Opa-interacting protein OIP2.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03018 - RNA degradation

-  Other Names for This Gene
  Alternate Gene Symbols: AF279901
UCSC ID: uc001uvz.2
RefSeq Accession: NM_181503

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AF279901.1
exon count: 11CDS single in 3' UTR: no RNA size: 798
ORF size: 0CDS single in intron: no Alignment % ID: 99.49
txCdsPredict score: 81.00frame shift in genome: no % Coverage: 95.61
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.