Description: Homo sapiens mitochondrial translational release factor 1 (MTRF1), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_004294): The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr13:41,808,026-41,835,506 Size: 27,481 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr13:41,808,027-41,835,043 Size: 27,017 Coding Exon Count: 6
ID:RF1M_HUMAN DESCRIPTION: RecName: Full=Peptide chain release factor 1, mitochondrial; Short=MRF-1; Short=MtRF-1; Flags: Precursor; FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA. SUBCELLULAR LOCATION: Mitochondrion. PTM: Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals (By similarity). SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75570
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
