Human Gene AKAP11 (uc001uys.2)
  Description: Homo sapiens A kinase (PRKA) anchor protein 11 (AKAP11), mRNA.
RefSeq Summary (NM_016248): The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chr13:42,846,289-42,897,403 Size: 51,115 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr13:42,860,485-42,893,364 Size: 32,880 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:42,846,289-42,897,403)mRNA (may differ from genome)Protein (1901 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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GeneNetworkH-INVHGNCHPRDLynxMGI
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AKA11_HUMAN
DESCRIPTION: RecName: Full=A-kinase anchor protein 11; Short=AKAP-11; AltName: Full=A-kinase anchor protein 220 kDa; Short=AKAP 220; Short=hAKAP220; AltName: Full=Protein kinase A-anchoring protein 11; Short=PRKA11;
FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
TISSUE SPECIFICITY: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.
DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
SIMILARITY: Belongs to the AKAP110 family.
SEQUENCE CAUTION: Sequence=BAA92117.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): AKAP11
CDC HuGE Published Literature: AKAP11
Positive Disease Associations: Bone mineral density (spine)
Related Studies:
  1. Bone mineral density (spine)
    Rivadeneira ,et al. 2009, Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies, Nature genetics 2009 41- 11 : 1199-206. [PubMed 19801982]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.26 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 460.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.61175-0.278 Picture PostScript Text
3' UTR -995.094039-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008382 - SPHK1-interactor_AKAP_110

ModBase Predicted Comparative 3D Structure on Q9UKA4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0051018 protein kinase A binding

Biological Process:
GO:0010738 regulation of protein kinase A signaling
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  CR627087 - Homo sapiens mRNA; cDNA DKFZp781I12161 (from clone DKFZp781I12161).
LF210174 - JP 2014500723-A/17677: Polycomb-Associated Non-Coding RNAs.
AF176555 - Homo sapiens A-kinase anchoring protein 220 mRNA, complete cds.
BC156135 - Synthetic construct Homo sapiens clone IMAGE:100062437, MGC:190513 A kinase (PRKA) anchor protein 11 (AKAP11) mRNA, encodes complete protein.
BC172498 - Synthetic construct Homo sapiens clone IMAGE:100069192, MGC:199203 A kinase (PRKA) anchor protein 11 (AKAP11) mRNA, encodes complete protein.
MA445751 - JP 2018138019-A/17677: Polycomb-Associated Non-Coding RNAs.
JD112757 - Sequence 93781 from Patent EP1572962.
LF335362 - JP 2014500723-A/142865: Polycomb-Associated Non-Coding RNAs.
LF335360 - JP 2014500723-A/142863: Polycomb-Associated Non-Coding RNAs.
LF335359 - JP 2014500723-A/142862: Polycomb-Associated Non-Coding RNAs.
LF335358 - JP 2014500723-A/142861: Polycomb-Associated Non-Coding RNAs.
LF335357 - JP 2014500723-A/142860: Polycomb-Associated Non-Coding RNAs.
AB014529 - Homo sapiens mRNA for KIAA0629 protein, partial cds.
LF335356 - JP 2014500723-A/142859: Polycomb-Associated Non-Coding RNAs.
LF335355 - JP 2014500723-A/142858: Polycomb-Associated Non-Coding RNAs.
LF335354 - JP 2014500723-A/142857: Polycomb-Associated Non-Coding RNAs.
LF335353 - JP 2014500723-A/142856: Polycomb-Associated Non-Coding RNAs.
LF335352 - JP 2014500723-A/142855: Polycomb-Associated Non-Coding RNAs.
LF335351 - JP 2014500723-A/142854: Polycomb-Associated Non-Coding RNAs.
AK002166 - Homo sapiens cDNA FLJ11304 fis, clone PLACE1009997, weakly similar to Rattus norvegicus A-kinase anchoring protein AKAP 220 mRNA.
LF335350 - JP 2014500723-A/142853: Polycomb-Associated Non-Coding RNAs.
LF335349 - JP 2014500723-A/142852: Polycomb-Associated Non-Coding RNAs.
LF335348 - JP 2014500723-A/142851: Polycomb-Associated Non-Coding RNAs.
LF335347 - JP 2014500723-A/142850: Polycomb-Associated Non-Coding RNAs.
LF335346 - JP 2014500723-A/142849: Polycomb-Associated Non-Coding RNAs.
LF335345 - JP 2014500723-A/142848: Polycomb-Associated Non-Coding RNAs.
LF335340 - JP 2014500723-A/142843: Polycomb-Associated Non-Coding RNAs.
JD299033 - Sequence 280057 from Patent EP1572962.
JD501649 - Sequence 482673 from Patent EP1572962.
JD301373 - Sequence 282397 from Patent EP1572962.
JD294875 - Sequence 275899 from Patent EP1572962.
JD349576 - Sequence 330600 from Patent EP1572962.
JD503752 - Sequence 484776 from Patent EP1572962.
JD299457 - Sequence 280481 from Patent EP1572962.
LF335333 - JP 2014500723-A/142836: Polycomb-Associated Non-Coding RNAs.
LF335332 - JP 2014500723-A/142835: Polycomb-Associated Non-Coding RNAs.
JD284944 - Sequence 265968 from Patent EP1572962.
JD566344 - Sequence 547368 from Patent EP1572962.
JD065496 - Sequence 46520 from Patent EP1572962.
LF335331 - JP 2014500723-A/142834: Polycomb-Associated Non-Coding RNAs.
JD338944 - Sequence 319968 from Patent EP1572962.
JD259835 - Sequence 240859 from Patent EP1572962.
JD163729 - Sequence 144753 from Patent EP1572962.
JD095654 - Sequence 76678 from Patent EP1572962.
JD325645 - Sequence 306669 from Patent EP1572962.
JD398421 - Sequence 379445 from Patent EP1572962.
JD123283 - Sequence 104307 from Patent EP1572962.
LF335330 - JP 2014500723-A/142833: Polycomb-Associated Non-Coding RNAs.
LF335329 - JP 2014500723-A/142832: Polycomb-Associated Non-Coding RNAs.
JD300219 - Sequence 281243 from Patent EP1572962.
AK074384 - Homo sapiens cDNA FLJ23804 fis, clone HEP22939.
JD063512 - Sequence 44536 from Patent EP1572962.
JD315403 - Sequence 296427 from Patent EP1572962.
JD202399 - Sequence 183423 from Patent EP1572962.
JD410561 - Sequence 391585 from Patent EP1572962.
LF335328 - JP 2014500723-A/142831: Polycomb-Associated Non-Coding RNAs.
JD280149 - Sequence 261173 from Patent EP1572962.
JD041917 - Sequence 22941 from Patent EP1572962.
JD432895 - Sequence 413919 from Patent EP1572962.
JD234374 - Sequence 215398 from Patent EP1572962.
JD160298 - Sequence 141322 from Patent EP1572962.
JD327435 - Sequence 308459 from Patent EP1572962.
LF335327 - JP 2014500723-A/142830: Polycomb-Associated Non-Coding RNAs.
JD400090 - Sequence 381114 from Patent EP1572962.
JD520746 - Sequence 501770 from Patent EP1572962.
JD305760 - Sequence 286784 from Patent EP1572962.
MA570939 - JP 2018138019-A/142865: Polycomb-Associated Non-Coding RNAs.
MA570937 - JP 2018138019-A/142863: Polycomb-Associated Non-Coding RNAs.
MA570936 - JP 2018138019-A/142862: Polycomb-Associated Non-Coding RNAs.
MA570935 - JP 2018138019-A/142861: Polycomb-Associated Non-Coding RNAs.
MA570934 - JP 2018138019-A/142860: Polycomb-Associated Non-Coding RNAs.
MA570933 - JP 2018138019-A/142859: Polycomb-Associated Non-Coding RNAs.
MA570932 - JP 2018138019-A/142858: Polycomb-Associated Non-Coding RNAs.
MA570931 - JP 2018138019-A/142857: Polycomb-Associated Non-Coding RNAs.
MA570930 - JP 2018138019-A/142856: Polycomb-Associated Non-Coding RNAs.
MA570929 - JP 2018138019-A/142855: Polycomb-Associated Non-Coding RNAs.
MA570928 - JP 2018138019-A/142854: Polycomb-Associated Non-Coding RNAs.
MA570927 - JP 2018138019-A/142853: Polycomb-Associated Non-Coding RNAs.
MA570926 - JP 2018138019-A/142852: Polycomb-Associated Non-Coding RNAs.
MA570925 - JP 2018138019-A/142851: Polycomb-Associated Non-Coding RNAs.
MA570924 - JP 2018138019-A/142850: Polycomb-Associated Non-Coding RNAs.
MA570923 - JP 2018138019-A/142849: Polycomb-Associated Non-Coding RNAs.
MA570922 - JP 2018138019-A/142848: Polycomb-Associated Non-Coding RNAs.
MA570917 - JP 2018138019-A/142843: Polycomb-Associated Non-Coding RNAs.
MA570910 - JP 2018138019-A/142836: Polycomb-Associated Non-Coding RNAs.
MA570909 - JP 2018138019-A/142835: Polycomb-Associated Non-Coding RNAs.
MA570908 - JP 2018138019-A/142834: Polycomb-Associated Non-Coding RNAs.
MA570907 - JP 2018138019-A/142833: Polycomb-Associated Non-Coding RNAs.
MA570906 - JP 2018138019-A/142832: Polycomb-Associated Non-Coding RNAs.
MA570905 - JP 2018138019-A/142831: Polycomb-Associated Non-Coding RNAs.
MA570904 - JP 2018138019-A/142830: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AKA11_HUMAN, AKAP220, KIAA0629, NM_016248, NP_057332, O75124, Q9NUK7, Q9UKA4
UCSC ID: uc001uys.2
RefSeq Accession: NM_016248
Protein: Q9UKA4 (aka AKA11_HUMAN or AK11_HUMAN)
CCDS: CCDS9383.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_016248.3
exon count: 13CDS single in 3' UTR: no RNA size: 9926
ORF size: 5706CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 11431.00frame shift in genome: no % Coverage: 99.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.