Description: Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 2, mRNA. RefSeq Summary (NM_203495): COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr13:76,099,350-76,111,991 Size: 12,642 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr13:76,100,725-76,111,941 Size: 11,217 Coding Exon Count: 4
ID:COMD6_HUMAN DESCRIPTION: RecName: Full=COMM domain-containing protein 6; FUNCTION: Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. SUBUNIT: Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Does not interact with NFKBIB. INTERACTION: Q8N668:COMMD1; NbExp=2; IntAct=EBI-1550081, EBI-1550112; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. SIMILARITY: Contains 1 COMM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z4G1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.