Description: Homo sapiens ribonuclease, RNase A family, 7 (RNASE7), mRNA. RefSeq Summary (NM_032572): The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]. Transcript (Including UTRs) Position: hg19 chr14:21,510,385-21,512,392 Size: 2,008 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr14:21,511,152-21,511,622 Size: 471 Coding Exon Count: 1
ID:RNAS7_HUMAN DESCRIPTION: RecName: Full=Ribonuclease 7; Short=RNase 7; EC=3.1.27.-; AltName: Full=Skin-derived antimicrobial protein 2; Short=SAP-2; Flags: Precursor; FUNCTION: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. SIMILARITY: Belongs to the pancreatic ribonuclease family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1E1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary