Human Gene IPO4 (uc001wmt.1)
  Description: Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:24,649,425-24,653,969 Size: 4,545 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr14:24,649,648-24,653,925 Size: 4,278 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,649,425-24,653,969)mRNA (may differ from genome)Protein (561 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7044-0.175 Picture PostScript Text
3' UTR -65.60223-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF13513 - HEAT-like repeat

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q8TEX9-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF210083 - JP 2014500723-A/17586: Polycomb-Associated Non-Coding RNAs.
AK027871 - Homo sapiens cDNA FLJ14965 fis, clone SKNMC1000011, weakly similar to PUTATIVE IMPORTIN BETA-4 SUBUNIT.
AK094897 - Homo sapiens cDNA FLJ37578 fis, clone BRCOC2003732, highly similar to Importin-4.
BC110804 - Homo sapiens importin 4, mRNA (cDNA clone MGC:131665 IMAGE:6164334), complete cds.
AK074743 - Homo sapiens cDNA FLJ90262 fis, clone NT2RM4000965, weakly similar to PUTATIVE IMPORTIN BETA-4 SUBUNIT.
AK057044 - Homo sapiens cDNA FLJ32482 fis, clone SKNMC2001324, highly similar to Importin-4.
AB208897 - Homo sapiens mRNA for IPO4 protein variant protein.
AK056527 - Homo sapiens cDNA FLJ31965 fis, clone NT2RP7007643, weakly similar to PUTATIVE IMPORTIN BETA-4 SUBUNIT.
BC003690 - Homo sapiens importin 4, mRNA (cDNA clone IMAGE:3452343), partial cds.
AK026991 - Homo sapiens cDNA: FLJ23338 fis, clone HEP13242.
AK056702 - Homo sapiens cDNA FLJ32140 fis, clone PLACE5000058, highly similar to Importin-4.
AK094107 - Homo sapiens cDNA FLJ36788 fis, clone ADRGL2004451, highly similar to Importin-4.
AK095306 - Homo sapiens cDNA FLJ37987 fis, clone CTONG2011429, highly similar to Importin-4.
AK057277 - Homo sapiens cDNA FLJ32715 fis, clone TESTI2000784, highly similar to Importin-4.
BX248267 - human full-length cDNA clone CS0DC014YJ21 of Neuroblastoma of Homo sapiens (human).
AK302097 - Homo sapiens cDNA FLJ58302 complete cds, highly similar to Importin-4.
BC136759 - Homo sapiens importin 4, mRNA (cDNA clone MGC:168372 IMAGE:9020749), complete cds.
BC144399 - Homo sapiens cDNA clone IMAGE:9052920.
BC144400 - Homo sapiens cDNA clone IMAGE:9052921, with apparent retained intron.
AB209476 - Homo sapiens mRNA for importin 4 variant protein.
JD104176 - Sequence 85200 from Patent EP1572962.
AF411122 - Homo sapiens importin 4 mRNA, complete cds.
JD535363 - Sequence 516387 from Patent EP1572962.
AK314305 - Homo sapiens cDNA, FLJ95062.
CR457367 - Homo sapiens full open reading frame cDNA clone RZPDo834C0521D for gene IPO4, importin 4; complete cds, incl. stopcodon.
LF334541 - JP 2014500723-A/142044: Polycomb-Associated Non-Coding RNAs.
LF334542 - JP 2014500723-A/142045: Polycomb-Associated Non-Coding RNAs.
LF334543 - JP 2014500723-A/142046: Polycomb-Associated Non-Coding RNAs.
LF334544 - JP 2014500723-A/142047: Polycomb-Associated Non-Coding RNAs.
CU678572 - Synthetic construct Homo sapiens gateway clone IMAGE:100020061 5' read IPO4 mRNA.
LF334545 - JP 2014500723-A/142048: Polycomb-Associated Non-Coding RNAs.
JD033929 - Sequence 14953 from Patent EP1572962.
JD023488 - Sequence 4512 from Patent EP1572962.
MA445660 - JP 2018138019-A/17586: Polycomb-Associated Non-Coding RNAs.
MA570118 - JP 2018138019-A/142044: Polycomb-Associated Non-Coding RNAs.
MA570119 - JP 2018138019-A/142045: Polycomb-Associated Non-Coding RNAs.
MA570120 - JP 2018138019-A/142046: Polycomb-Associated Non-Coding RNAs.
MA570121 - JP 2018138019-A/142047: Polycomb-Associated Non-Coding RNAs.
MA570122 - JP 2018138019-A/142048: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK074743, IMP4B, NM_024658, NP_078934, Q8TEX9-2, RANBP4
UCSC ID: uc001wmt.1
RefSeq Accession: NM_024658
Protein: Q8TEX9-2, splice isoform of Q8TEX9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK074743.1
exon count: 15CDS single in 3' UTR: no RNA size: 1864
ORF size: 1686CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3536.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.