Human Gene DHRS1 (uc001woj.2)
  Description: Homo sapiens dehydrogenase/reductase (SDR family) member 1 (DHRS1), transcript variant 2, mRNA.
RefSeq Summary (NM_138452): This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008].
Transcript (Including UTRs)
   Position: hg19 chr14:24,759,804-24,768,666 Size: 8,863 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr14:24,760,065-24,768,312 Size: 8,248 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,759,804-24,768,666)mRNA (may differ from genome)Protein (313 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DHRS1_HUMAN
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 1; EC=1.1.-.-;
TISSUE SPECIFICITY: Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DHRS1
CDC HuGE Published Literature: DHRS1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 53.02 RPKM in Esophagus - Mucosa
Total median expression: 640.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.24269-0.317 Picture PostScript Text
3' UTR -59.94261-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom

Pfam Domains:
PF00106 - short chain dehydrogenase
PF08659 - KR domain
PF13561 - Enoyl-(Acyl carrier protein) reductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2QQ5 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96LJ7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  KJ906409 - Synthetic construct Homo sapiens clone ccsbBroadEn_16079 DHRS1 gene, encodes complete protein.
KJ900028 - Synthetic construct Homo sapiens clone ccsbBroadEn_09422 DHRS1 gene, encodes complete protein.
AL050217 - Homo sapiens mRNA; cDNA DKFZp586I0523 (from clone DKFZp586I0523).
BC036845 - Homo sapiens dehydrogenase/reductase (SDR family) member 1, mRNA (cDNA clone IMAGE:5241019), with apparent retained intron.
AL833917 - Homo sapiens mRNA; cDNA DKFZp564G012 (from clone DKFZp564G012).
BC014057 - Homo sapiens dehydrogenase/reductase (SDR family) member 1, mRNA (cDNA clone MGC:20204 IMAGE:3622913), complete cds.
AK126383 - Homo sapiens cDNA FLJ44419 fis, clone UTERU2002176.
AK058159 - Homo sapiens cDNA FLJ25430 fis, clone TST06262.
BC015943 - Homo sapiens dehydrogenase/reductase (SDR family) member 1, mRNA (cDNA clone MGC:9325 IMAGE:3922816), complete cds.
AF418205 - Homo sapiens dehydrogenase/reductase SDR family member 1 (DHRS1) mRNA, complete cds.
BX247980 - human full-length cDNA clone CS0DF026YA08 of Fetal brain of Homo sapiens (human).
JD232534 - Sequence 213558 from Patent EP1572962.
JD204292 - Sequence 185316 from Patent EP1572962.
JD101264 - Sequence 82288 from Patent EP1572962.
JD504718 - Sequence 485742 from Patent EP1572962.
AB463565 - Synthetic construct DNA, clone: pF1KB8333, Homo sapiens DHRS1 gene for dehydrogenase/reductase (SDR family) member 1, without stop codon, in Flexi system.
AM393043 - Synthetic construct Homo sapiens clone IMAGE:100003072 for hypothetical protein (DHRS1 gene).
AM393592 - Synthetic construct Homo sapiens clone IMAGE:100001948 for hypothetical protein (DHRS1 gene).
CU677527 - Synthetic construct Homo sapiens gateway clone IMAGE:100017011 5' read DHRS1 mRNA.
JD136686 - Sequence 117710 from Patent EP1572962.
JD174209 - Sequence 155233 from Patent EP1572962.
JD107168 - Sequence 88192 from Patent EP1572962.
JD120346 - Sequence 101370 from Patent EP1572962.
JD414316 - Sequence 395340 from Patent EP1572962.
JD331589 - Sequence 312613 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DS71, DHRS1_HUMAN, NM_138452, NP_612461, Q8NDG3, Q96B59, Q96CQ5, Q96LJ7
UCSC ID: uc001woj.2
RefSeq Accession: NM_138452
Protein: Q96LJ7 (aka DHRS1_HUMAN or DHS1_HUMAN)
CCDS: CCDS9623.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_138452.2
exon count: 9CDS single in 3' UTR: no RNA size: 1488
ORF size: 942CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2084.00frame shift in genome: no % Coverage: 98.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.