Human Gene KLHL28 (uc001wvq.4)
Description: Homo sapiens kelch-like family member 28 (KLHL28), mRNA.
Transcript (Including UTRs)
Position: hg19 chr14:45,393,527-45,430,335 Size: 36,809 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr14:45,398,231-45,430,131 Size: 31,901 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: J3KNY7_HUMAN
DESCRIPTION: SubName: Full=BTB (POZ) domain containing 5, isoform CRA_d; SubName: Full=Kelch-like protein 28;
SIMILARITY: Contains 1 BTB (POZ) domain.SIMILARITY: Contains 6 Kelch repeats.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015916 - Gal_Oxidase_b-propeller
IPR017096 - Kelch-like_gigaxonin
IPR006652 - Kelch_1
Pfam Domains: PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13964 - Kelch motif
SCOP Domains: 101898 - NHL repeat
50965 - Galactose oxidase, central domain
54695 - POZ domain
ModBase Predicted Comparative 3D Structure on J3KNY7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
AK090972 - Homo sapiens cDNA FLJ33653 fis, clone BRAMY2024715.JD144574 - Sequence 125598 from Patent EP1572962.JD275238 - Sequence 256262 from Patent EP1572962.JD497081 - Sequence 478105 from Patent EP1572962.AK289855 - Homo sapiens cDNA FLJ76338 complete cds, highly similar to Homo sapiens BTB (POZ) domain containing 5 (BTBD5), mRNA.BC057794 - Homo sapiens cDNA clone IMAGE:5295395, containing frame-shift errors.BC121009 - Homo sapiens kelch-like 28 (Drosophila), mRNA (cDNA clone MGC:149636 IMAGE:40116967), complete cds.BC121010 - Homo sapiens kelch-like 28 (Drosophila), mRNA (cDNA clone MGC:149637 IMAGE:40116970), complete cds.KJ894068 - Synthetic construct Homo sapiens clone ccsbBroadEn_03462 KLHL28 gene, encodes complete protein.KJ906201 - Synthetic construct Homo sapiens clone ccsbBroadEn_15871 KLHL28 gene, encodes complete protein.BC012473 - Homo sapiens cDNA clone IMAGE:4453077, containing frame-shift errors.AK000088 - Homo sapiens cDNA FLJ20081 fis, clone COL03242.AK225183 - Homo sapiens mRNA for BTB (POZ) domain containing 5 variant, clone: COL03244.AK225211 - Homo sapiens mRNA for BTB (POZ) domain containing 5 variant, clone: COL03242.JD296441 - Sequence 277465 from Patent EP1572962.JD327479 - Sequence 308503 from Patent EP1572962.JD564165 - Sequence 545189 from Patent EP1572962.JD185826 - Sequence 166850 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: BC057794, BTBD5, hCG_20873, J3KNY7, J3KNY7_HUMAN, NM_017658, NP_060128, uc001wvq.3UCSC ID: uc001wvq.4RefSeq Accession: NM_017658
Protein: J3KNY7
CCDS: CCDS9680.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
BC057794.1
exon count:
5 CDS single in 3' UTR:
no
RNA size:
2189
ORF size:
1758 CDS single in intron:
no
Alignment % ID:
99.91
txCdsPredict score:
3562.50 frame shift in genome:
no
% Coverage:
99.36
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.