ID:FERM2_HUMAN DESCRIPTION: RecName: Full=Fermitin family homolog 2; AltName: Full=Kindlin-2; AltName: Full=Mitogen-inducible gene 2 protein; Short=MIG-2; AltName: Full=Pleckstrin homology domain-containing family C member 1; Short=PH domain-containing family C member 1; FUNCTION: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. SUBUNIT: Interacts with FBLP1. SUBCELLULAR LOCATION: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Within actin stress fibers at cell-ECM focal adhesion sites. TISSUE SPECIFICITY: Ubiquitous. Found in numerous tumor tissues. INDUCTION: By serum in lung fetal fibroblast cultured cells. DOMAIN: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. SIMILARITY: Belongs to the kindlin family. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=CAA80852.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=FERMT2 entry; URL="http://en.wikipedia.org/wiki/FERMT2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AC1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.