Description: Homo sapiens RAD51 homolog B (S. cerevisiae) (RAD51B), transcript variant 2, mRNA. RefSeq Summary (NM_133510): The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]. Transcript (Including UTRs) Position: hg19 chr14:68,286,496-69,196,935 Size: 910,440 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr14:68,290,261-69,117,562 Size: 827,302 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00154 - recA bacterial DNA recombination protein PF03796 - DnaB-like helicase C terminal domain PF06745 - KaiC PF08423 - Rad51 PF13481 - AAA domain
ModBase Predicted Comparative 3D Structure on O15315-4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK309787 - Homo sapiens cDNA, FLJ99828. U92074 - Human RecA-like protein (hREC2) mRNA, complete cds. U84138 - Homo sapiens DNA repair protein RAD51B mRNA, complete cds. Y15571 - Homo sapiens mRNA for recombination repair protein (R51H2). AK310686 - Homo sapiens cDNA, FLJ17728. BC030219 - Homo sapiens RAD51-like 1 (S. cerevisiae), mRNA (cDNA clone MGC:34245 IMAGE:5206768), complete cds. BX161515 - human full-length cDNA clone CS0DL003YE20 of B cells (Ramos cell line) of Homo sapiens (human). BX248766 - human full-length cDNA 5-PRIME end of clone CS0DD005YC06 of Neuroblastoma of Homo sapiens (human). BX248061 - human full-length cDNA clone CS0DJ004YI08 of T cells (Jurkat cell line) of Homo sapiens (human). CU688846 - Synthetic construct Homo sapiens gateway clone IMAGE:100018189 5' read RAD51L1 mRNA. KJ891975 - Synthetic construct Homo sapiens clone ccsbBroadEn_01369 RAD51B gene, encodes complete protein. AB528442 - Synthetic construct DNA, clone: pF1KB6512, Homo sapiens RAD51L1 gene for RAD51-like 1, without stop codon, in Flexi system. DQ894081 - Synthetic construct Homo sapiens clone IMAGE:100008541; FLH167470.01L; RZPDo839B0189D RAD51-like 1 (S. cerevisiae) (RAD51L1) gene, encodes complete protein. DQ890926 - Synthetic construct clone IMAGE:100003556; FLH167474.01X; RZPDo839B0190D RAD51-like 1 (S. cerevisiae) (RAD51L1) gene, encodes complete protein. CR536560 - Homo sapiens full open reading frame cDNA clone RZPDo834E1220D for gene RAD51L1, RAD51-like 1 (S. cerevisiae); complete cds, incl. stopcodon. AY138857 - Homo sapiens clone C93 HMGA2/RAD51L1 fusion (HMGA2/RAD51L1 fusion) mRNA, partial cds. AY138858 - Homo sapiens clone D30 HMGA2/RAD51L1 fusion (HMGA2/RAD51L1 fusion) mRNA, partial cds. AY138859 - Homo sapiens clone A5 HMGA2/RAD51L1 fusion (HMGA2/RAD51L1 fusion) mRNA, partial cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03440 - Homologous recombination
Reactome (by CSHL, EBI, and GO)
Protein O15315 (Reactome details) participates in the following event(s):
R-HSA-983285 RAD51B binds RAD51C R-HSA-5685318 BCDX2 complex formation R-HSA-983218 RAD51B:RAD51C binds single-stranded DNA R-HSA-5685341 BCDX2 complex stabilizes RAD51 filament R-HSA-5686410 BLM mediates dissolution of double Holliday junction R-HSA-5693589 D-loop dissociation and strand annealing R-HSA-5693620 D-loop formation mediated by PALB2, BRCA2 and RAD51 R-HSA-5685838 CX3 complex binds D-loop structures R-HSA-5693593 D-loop extension by DNA polymerases R-HSA-5693584 Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) R-HSA-5686440 MUS81:EME1,EME2 cleaves D-loop R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-109582 Hemostasis R-HSA-5693579 Homologous DNA Pairing and Strand Exchange R-HSA-5693537 Resolution of D-Loop Structures R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693538 Homology Directed Repair R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-73894 DNA Repair
US Server
