Human Gene DGLUCY (uc001xyw.2)
  Description: Homo sapiens chromosome 14 open reading frame 159 (DGLUCY), transcript variant 4, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:91,580,357-91,691,703 Size: 111,347 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr14:91,626,639-91,691,177 Size: 64,539 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:91,580,357-91,691,703)mRNA (may differ from genome)Protein (621 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHPRD
LynxMGIPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.15 RPKM in Heart - Left Ventricle
Total median expression: 485.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.90352-0.361 Picture PostScript Text
3' UTR -157.30526-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF07286 - Protein of unknown function (DUF1445)
PF14336 - Domain of unknown function (DUF4392)

ModBase Predicted Comparative 3D Structure on Q7Z3D6-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK097294 - Homo sapiens cDNA FLJ39975 fis, clone SPLEN2028466.
AK098752 - Homo sapiens cDNA FLJ25886 fis, clone CBR02987.
BX537970 - Homo sapiens mRNA; cDNA DKFZp686J0759 (from clone DKFZp686J0759); complete cds.
BX161393 - human full-length cDNA clone CS0DC008YJ24 of Neuroblastoma of Homo sapiens (human).
BX247989 - human full-length cDNA clone CS0DG002YH18 of B cells (Ramos cell line) of Homo sapiens (human).
BC009182 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone IMAGE:3943486), complete cds.
AK308857 - Homo sapiens cDNA, FLJ98898.
AB210031 - Homo sapiens mRNA for C14orf159 variant protein, clone: hh05718.
AK023200 - Homo sapiens cDNA FLJ13138 fis, clone NT2RP3003197, weakly similar to HYPOTHETICAL 33.8 KD PROTEIN C5H10.01 IN CHROMOSOME I.
AK123532 - Homo sapiens cDNA FLJ41538 fis, clone BRTHA2018129.
BC065558 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone MGC:74715 IMAGE:6138321), complete cds.
BX248782 - human full-length cDNA 5-PRIME end of clone CS0DL008YE07 of B cells (Ramos cell line) of Homo sapiens (human).
AK091394 - Homo sapiens cDNA FLJ34075 fis, clone FCBBF3003216.
AK022564 - Homo sapiens cDNA FLJ12502 fis, clone NT2RM2001688, weakly similar to HYPOTHETICAL 33.8 KD PROTEIN C5H10.01 IN CHROMOSOME I.
BX248060 - human full-length cDNA clone CS0DJ004YG22 of T cells (Jurkat cell line) of Homo sapiens (human).
BC010614 - Homo sapiens chromosome 14 open reading frame 159, mRNA (cDNA clone MGC:16855 IMAGE:4157432), complete cds.
AY358516 - Homo sapiens clone DNA59774 PFTL2439 (UNQ2439) mRNA, complete cds.
JD347876 - Sequence 328900 from Patent EP1572962.
AM393118 - Synthetic construct Homo sapiens clone IMAGE:100001990 for hypothetical protein (C14orf159 gene).
KJ903267 - Synthetic construct Homo sapiens clone ccsbBroadEn_12661 C14orf159 gene, encodes complete protein.
CU679757 - Synthetic construct Homo sapiens gateway clone IMAGE:100020761 5' read C14orf159 mRNA.
AB384381 - Synthetic construct DNA, clone: pF1KSDB0052, Homo sapiens C14orf159 gene for chromosome 14 open reading frame protein 159, complete cds, without stop codon, in Flexi system.
CR457289 - Homo sapiens full open reading frame cDNA clone RZPDo834C0921D for gene C14orf159, chromosome 14 open reading frame 159; complete cds, incl. stopcodon.
KJ899604 - Synthetic construct Homo sapiens clone ccsbBroadEn_08998 C14orf159 gene, encodes complete protein.
BX248294 - human full-length cDNA clone CS0DJ010YP09 of T cells (Jurkat cell line) of Homo sapiens (human).
BC011545 - Homo sapiens mRNA similar to hypothetical protein FLJ20950 (cDNA clone IMAGE:4639229).
AK222531 - Homo sapiens mRNA for chromosome 14 open reading frame 159 variant, clone: adSE01927.
AK024603 - Homo sapiens cDNA: FLJ20950 fis, clone ADSE01927.
AY927602 - Homo sapiens mRNA sequence.
BX647492 - Homo sapiens mRNA; cDNA DKFZp686I02128 (from clone DKFZp686I02128).
AK097262 - Homo sapiens cDNA FLJ39943 fis, clone SPLEN2023118.
JD185171 - Sequence 166195 from Patent EP1572962.
JD307359 - Sequence 288383 from Patent EP1572962.
JD168701 - Sequence 149725 from Patent EP1572962.
JD308630 - Sequence 289654 from Patent EP1572962.
JD053157 - Sequence 34181 from Patent EP1572962.
JD225553 - Sequence 206577 from Patent EP1572962.
JD298703 - Sequence 279727 from Patent EP1572962.
JD089696 - Sequence 70720 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C14orf159, NM_001102368, NP_001095838, Q7Z3D6-2, UNQ2439/PRO5000
UCSC ID: uc001xyw.2
RefSeq Accession: NM_001102368
Protein: Q7Z3D6-2, splice isoform of Q7Z3D6 CCDS: CCDS32141.1, CCDS41979.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001102368.1
exon count: 14CDS single in 3' UTR: no RNA size: 2763
ORF size: 1866CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3487.00frame shift in genome: no % Coverage: 99.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.