Description: Homo sapiens tryptophanyl-tRNA synthetase (WARS1), transcript variant 2, mRNA. RefSeq Summary (NM_173701): Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr14:100,800,125-100,842,680 Size: 42,556 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr14:100,801,212-100,835,522 Size: 34,311 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23381
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001525 angiogenesis GO:0001933 negative regulation of protein phosphorylation GO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006436 tryptophanyl-tRNA aminoacylation GO:0006469 negative regulation of protein kinase activity GO:0008285 negative regulation of cell proliferation GO:0010628 positive regulation of gene expression GO:0010835 regulation of protein ADP-ribosylation GO:0031334 positive regulation of protein complex assembly GO:0045765 regulation of angiogenesis
US Server
